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Table 4 Associations of circadian pathway genes with susceptibility to melanoma under the additive model of inheritance. Stratification by gender and by age

From: Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility

GENE SNP ID FEMALES MALES
OR 95%CI P-value OR 95%CI P-value
AANAT rs3760138 0.95 [0.75–1.21] 0.693 0.98 [0.77–1.24] 0.850
  rs11077821 0.89 [0.64–1.25] 0.505 1.03 [0.75–1.41] 0.874
CLOCK rs1801260 0.90 [0.69–1.17] 0.423 0.96 [0.74–1.24] 0.724
  rs3736544 0.75 [0.59–0.96] 0.021 1.24 [0.98–1.57] 0.074
  rs3749474 1.33 [1.05–1.68] 0.018 0.79 [0.62–1.01] 0.058
NPAS2 rs2305160 1.09 [0.84–1.41] 0.529 0.97 [0.75–1.24] 0.789
PER1 rs3027178 0.94 [0.74–1.20] 0.633 1.11 [0.87–1.41] 0.416
PER2 rs2304674 1.12 [0.86–1.47] 0.405 1.01 [0.76–1.32] 0.971
  rs934945 0.87 [0.64–1.19] 0.393 0.93 [0.68–1.26] 0.618
RORA rs339972 0.67 [0.51–0.88] 0.003 0.84 [0.65–1.09] 0.181
  rs10519097 0.93 [0.67–1.30] 0.673 0.62 [0.44–0.87] 0.005
TIMELESS rs3809125 1.05 [0.82–1.34] 0.701 0.95 [0.74–1.21] 0.668
  rs7302060 1.00 [0.79–1.26] 0.994 1.07 [0.85–1.35] 0.564
  rs774027 1.05 [0.84–1.33] 0.659 0.97 [0.77–1.22] 0.805
Age
   < 50 years     
 RORA rs339972 0.84 [0.68–1.04] 0.100    
  rs10519097 0.83 [0.63–1.09] 0.180    
   > 50 years     
 RORA rs339972 0.67 [0.54–0.83] 0.0002    
  rs10519097 0.83 [0.64–1.08] 0.158