Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility

Table 4 Associations of circadian pathway genes with susceptibility to melanoma under the additive model of inheritance. Stratification by gender and by age

GENE	SNP ID	FEMALES			MALES
GENE	SNP ID	OR	95%CI	P-value	OR	95%CI	P-value
AANAT	rs3760138	0.95	[0.75–1.21]	0.693	0.98	[0.77–1.24]	0.850
	rs11077821	0.89	[0.64–1.25]	0.505	1.03	[0.75–1.41]	0.874
CLOCK	rs1801260	0.90	[0.69–1.17]	0.423	0.96	[0.74–1.24]	0.724
	rs3736544	0.75	[0.59–0.96]	0.021	1.24	[0.98–1.57]	0.074
	rs3749474	1.33	[1.05–1.68]	0.018	0.79	[0.62–1.01]	0.058
NPAS2	rs2305160	1.09	[0.84–1.41]	0.529	0.97	[0.75–1.24]	0.789
PER1	rs3027178	0.94	[0.74–1.20]	0.633	1.11	[0.87–1.41]	0.416
PER2	rs2304674	1.12	[0.86–1.47]	0.405	1.01	[0.76–1.32]	0.971
	rs934945	0.87	[0.64–1.19]	0.393	0.93	[0.68–1.26]	0.618
RORA	rs339972	0.67	[0.51–0.88]	0.003	0.84	[0.65–1.09]	0.181
	rs10519097	0.93	[0.67–1.30]	0.673	0.62	[0.44–0.87]	0.005
TIMELESS	rs3809125	1.05	[0.82–1.34]	0.701	0.95	[0.74–1.21]	0.668
	rs7302060	1.00	[0.79–1.26]	0.994	1.07	[0.85–1.35]	0.564
	rs774027	1.05	[0.84–1.33]	0.659	0.97	[0.77–1.22]	0.805
Age
	< 50 years
RORA	rs339972	0.84	[0.68–1.04]	0.100
	rs10519097	0.83	[0.63–1.09]	0.180
	> 50 years
RORA	rs339972	0.67	[0.54–0.83]	0.0002
	rs10519097	0.83	[0.64–1.08]	0.158

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