Table 2 Genotypes and main features of the circadian gene SNPs

AANAT

rs3760138

TT

146 (24.3)

173 (27.7)

intron

5′-UTR

[28]

TG

323 (53.7)

302 (48.3)

GG

132 (22.0)

150 (24.0)

rs11077821

CC

419 (69.1)

448 (71.5)

intron

[29]

CT

175 (28.9)

166 (26.5)

TT

12 ( 2.0)

13 ( 2.1)

CLOCK

rs1801260

TT

323 (53.2)

336 (53.4)

3′-UTR

[13, 14, 20, 22, 24, 30,31,32,33,34]

TC

228 (37.6)

251 (39.9)

CC

56 ( 9.2)

42 ( 6.7)

rs3736544

GG

241 (39.8)

253 (40.2)

exon

Asn > Asn

GA

269 (44.5)

294 (46.7)

AA

95 (15.7)

82 (13.0)

rs3749474

CC

259 (42.6)

258 (41.0)

3′-UTR

[14, 19, 20, 28, 34]

CT

266 (43.8)

280 (44.5)

TT

83 (13.7)

91 (14.5)

NPAS2

rs2305160

GG

283 (46.7)

273 (44.0)

exon

Thr > Ala

[14, 16, 18, 23, 24, 28, 29, 34,35,36,37,38,39,40,41,42,43]

GA

264 (43.6)

290 (46.7)

AA

59 ( 9.7)

58 ( 9.3)

PER1

rs3027178

TT

281 (46.1)

262 (42.4)

exon

Thr > Thr

[14, 19, 25, 44]

TG

253 (41.5)

279 (45.1)

GG

76 (12.5)

77 (12.5)

PER2

rs934945

CC

386 (63.4)

410 (66.1)

exon

Gly > Glu

[13, 14, 19, 21,22,23,24,25, 44]

CT

206 (33.8)

194 (31.3)

TT

17 ( 2.8)

16 ( 2.6)

PER2

rs2304674

AA

330 (54.5)

349 (55.8)

intron

[23, 24, 29]

AG

246 (40.7)

232 (37.1)

GG

29 ( 4.8)

45 ( 7.2)

RORA

rs339972

TT

312 (51.4)

349 (55.7)

intron

[13, 14, 19, 24]

TC

233 (38.4)

244 (38.9)

CC

62 (10.2)

34 ( 5.4)

rs10519097

CC

422 (69.3)

464 (74.4)

intron

[13, 14, 19, 24]

CT

173 (28.4)

151 (24.2)

TT

14 ( 2.3)

9 ( 1.4)

TIMELESS

rs3809125

CC

250 (41.4)

258 (41.0)

exon

Ile > Val

CT

280 (46.4)

297 (47.2)

TT

74 (12.3)

74 (11.8)

rs7302060

TT

181 (29.9)

192 (30.6)

upstream

[13,14,15,16,17, 19]

TC

304 (50.2)

299 (47.6)

CC

121 (20.0)

137 (21.8)

rs774027

AA

157 (25.9)

164 (26.1)

intron

[13, 18, 19, 24, 39]

AT

301 (49.7)

303 (48.2)

TT

148 (24.4)

162 (25.8)