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Table 2 Genotypes and main features of the circadian gene SNPs

From: Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility

Gene SNP ID Genotype Controls
N (%)
Cases
N (%)
Chr Region Residue
change
References in cancer
AANAT rs3760138 TT 146 (24.3) 173 (27.7) 17 intron
5′-UTR
  [28]
   TG 323 (53.7) 302 (48.3)     
   GG 132 (22.0) 150 (24.0)     
  rs11077821 CC 419 (69.1) 448 (71.5) 17 intron   [29]
   CT 175 (28.9) 166 (26.5)     
   TT 12 ( 2.0) 13 ( 2.1)     
CLOCK rs1801260 TT 323 (53.2) 336 (53.4) 4 3′-UTR   [13, 14, 20, 22, 24, 30,31,32,33,34]
   TC 228 (37.6) 251 (39.9)     
   CC 56 ( 9.2) 42 ( 6.7)     
  rs3736544 GG 241 (39.8) 253 (40.2) 4 exon Asn > Asn  
   GA 269 (44.5) 294 (46.7)     
   AA 95 (15.7) 82 (13.0)     
  rs3749474 CC 259 (42.6) 258 (41.0) 4 3′-UTR   [14, 19, 20, 28, 34]
   CT 266 (43.8) 280 (44.5)     
   TT 83 (13.7) 91 (14.5)     
NPAS2 rs2305160 GG 283 (46.7) 273 (44.0) 2 exon Thr > Ala [14, 16, 18, 23, 24, 28, 29, 34,35,36,37,38,39,40,41,42,43]
   GA 264 (43.6) 290 (46.7)     
   AA 59 ( 9.7) 58 ( 9.3)     
PER1 rs3027178 TT 281 (46.1) 262 (42.4) 17 exon Thr > Thr [14, 19, 25, 44]
   TG 253 (41.5) 279 (45.1)     
   GG 76 (12.5) 77 (12.5)     
PER2 rs934945 CC 386 (63.4) 410 (66.1) 2 exon Gly > Glu [13, 14, 19, 21,22,23,24,25, 44]
   CT 206 (33.8) 194 (31.3)     
   TT 17 ( 2.8) 16 ( 2.6)     
PER2 rs2304674 AA 330 (54.5) 349 (55.8) 2 intron   [23, 24, 29]
   AG 246 (40.7) 232 (37.1)     
   GG 29 ( 4.8) 45 ( 7.2)     
RORA rs339972 TT 312 (51.4) 349 (55.7) 15 intron   [13, 14, 19, 24]
   TC 233 (38.4) 244 (38.9)     
   CC 62 (10.2) 34 ( 5.4)     
  rs10519097 CC 422 (69.3) 464 (74.4) 15 intron   [13, 14, 19, 24]
   CT 173 (28.4) 151 (24.2)     
   TT 14 ( 2.3) 9 ( 1.4)     
TIMELESS rs3809125 CC 250 (41.4) 258 (41.0) 12 exon Ile > Val  
   CT 280 (46.4) 297 (47.2)     
   TT 74 (12.3) 74 (11.8)     
  rs7302060 TT 181 (29.9) 192 (30.6) 12 upstream   [13,14,15,16,17, 19]
   TC 304 (50.2) 299 (47.6)     
   CC 121 (20.0) 137 (21.8)     
  rs774027 AA 157 (25.9) 164 (26.1) 12 intron   [13, 18, 19, 24, 39]
   AT 301 (49.7) 303 (48.2)     
   TT 148 (24.4) 162 (25.8)