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Table 1 Clinicopathological factors associated with baseline ctDNA level

From: Circulating tumor DNA as a prognostic marker in high-risk endometrial cancer

  Median cfDNA level copies per ml (median,interquartile range) P value Mutant copies per ml (median,interquartile range) P value Mutant allele fraction % P value ctDNA detection P value
Age
 Below 60 184,370 (105,485–264,285) 0.796 370 (185–745) 1 0.2 0.793 2/3 (67%) 1
 Above 60 56,330 (43,245–70,015)   60 (15–1395)   0.115   4/6 (67%)  
Pathology subtype
 Endometroid 64,060 (/) 0.42 60 (/) 0.467 0.09 0.568 1/1 (100%) 0.446
 Clear cell 693,400 (/)   1840 (/)   2.65   1/1 (100%)  
 Serous 45,030 (36,615–150,427.5)   215(15–932.5)   0.17   4/6 (67%)  
 Dedifferentiated 72,000 (/)   0 (/)   0   0/1 (0%)  
FIGO stage
 I–II 38,230 (32,900–49,095) 0.05 0 (0–15) 0.017 0.07 0.025 1/4 (25%) 0.025
 III–IV 184,370 (64,060–344,200)   1120 (370–1840)   2.65   5/5 (100%)  
Tumor size
 <  = 5 cm 52,760 (37,745–94,137.5) 0.327 60 (45–137.5) 0.453 0.115 0.455 3/4 (75%) 0.655
 > 5 cm 72,000 (48,600–344,200)   1120 (0–1840)   2.65   3/5 (60%)  
Depth of invasion
 Superficial 38,230 (32,900–77,187.5) 0.086 30 (0–137.5) 0.169 0.07 0.213 2/4 (50%) 0.371
 Deep 72,000 (64,060–344,200)   1120 (370–1840)   2.65   4/5 (80%)  
Node positive
 Yes 184,370 (64,060–344,200) 0.05 1120 (370–1840) 0.017 2.65 0.025 5/5 (100%) 0.025
 No 38,230 (32,900–49,095)   0 (0–15)   0.07   1/4 (25%)  
LVSI
 Yes 128,185 (54,450–304,242.5) 0.142 745 (92.5–1660) 1 1.425 1 2/3 (67%) 0.655
 No 41,460 (38,230–52,760)   60 (30–60)   0.09   4/6 (67%)  
Involvement of lower uterine segment
 Yes 68,030 (52,465–276,150) 0.439 590 (15–1660) 0.51 1.37 0.599 2/3 (67%) 1
 No 41,460 (38,230–112,915)   60 (30–215)   0.14   4/6 (67%)  
  1. P values for association between clinicopathological factors and baseline ctDNA level (median cfDNA levels, mutant copies, mutant allele fraction and ctDNA detection rate) were determined. Advanced FIGO stage and node metastasis were associated with high level of mutant copies and mutant allele fraction of ctDNA (FIGO stage: p = 0.017/0.025, node status: p = 0.017/0.025) and high detection rate of ctDNA (p = 0.025, both)