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Table 1 Clinicopathological factors associated with baseline ctDNA level

From: Circulating tumor DNA as a prognostic marker in high-risk endometrial cancer

 

Median cfDNA level copies per ml (median,interquartile range)

P value

Mutant copies per ml (median,interquartile range)

P value

Mutant allele fraction %

P value

ctDNA detection

P value

Age

 Below 60

184,370 (105,485–264,285)

0.796

370 (185–745)

1

0.2

0.793

2/3 (67%)

1

 Above 60

56,330 (43,245–70,015)

 

60 (15–1395)

 

0.115

 

4/6 (67%)

 

Pathology subtype

 Endometroid

64,060 (/)

0.42

60 (/)

0.467

0.09

0.568

1/1 (100%)

0.446

 Clear cell

693,400 (/)

 

1840 (/)

 

2.65

 

1/1 (100%)

 

 Serous

45,030 (36,615–150,427.5)

 

215(15–932.5)

 

0.17

 

4/6 (67%)

 

 Dedifferentiated

72,000 (/)

 

0 (/)

 

0

 

0/1 (0%)

 

FIGO stage

 I–II

38,230 (32,900–49,095)

0.05

0 (0–15)

0.017

0.07

0.025

1/4 (25%)

0.025

 III–IV

184,370 (64,060–344,200)

 

1120 (370–1840)

 

2.65

 

5/5 (100%)

 

Tumor size

 <  = 5 cm

52,760 (37,745–94,137.5)

0.327

60 (45–137.5)

0.453

0.115

0.455

3/4 (75%)

0.655

 > 5 cm

72,000 (48,600–344,200)

 

1120 (0–1840)

 

2.65

 

3/5 (60%)

 

Depth of invasion

 Superficial

38,230 (32,900–77,187.5)

0.086

30 (0–137.5)

0.169

0.07

0.213

2/4 (50%)

0.371

 Deep

72,000 (64,060–344,200)

 

1120 (370–1840)

 

2.65

 

4/5 (80%)

 

Node positive

 Yes

184,370 (64,060–344,200)

0.05

1120 (370–1840)

0.017

2.65

0.025

5/5 (100%)

0.025

 No

38,230 (32,900–49,095)

 

0 (0–15)

 

0.07

 

1/4 (25%)

 

LVSI

 Yes

128,185 (54,450–304,242.5)

0.142

745 (92.5–1660)

1

1.425

1

2/3 (67%)

0.655

 No

41,460 (38,230–52,760)

 

60 (30–60)

 

0.09

 

4/6 (67%)

 

Involvement of lower uterine segment

 Yes

68,030 (52,465–276,150)

0.439

590 (15–1660)

0.51

1.37

0.599

2/3 (67%)

1

 No

41,460 (38,230–112,915)

 

60 (30–215)

 

0.14

 

4/6 (67%)

 
  1. P values for association between clinicopathological factors and baseline ctDNA level (median cfDNA levels, mutant copies, mutant allele fraction and ctDNA detection rate) were determined. Advanced FIGO stage and node metastasis were associated with high level of mutant copies and mutant allele fraction of ctDNA (FIGO stage: p = 0.017/0.025, node status: p = 0.017/0.025) and high detection rate of ctDNA (p = 0.025, both)