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Table 3 Predicting value of DD, AFP and free β-hCG separate or joint screening for GH, PE, SPE and HDP

From: Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case–control study

Groups (n) screening indicators

AUC

95%CI

P

Cut-off

Sensitivity

Specificity

Youden index

GH (126)

 DD

0.642

0.573–0.711

 < 0.001*

0.755

1.000

0.324

0.324

 AFP

0.537

0.467–0.608

0.295

0.875

0.667

0.426

0.093

 Free β-hCG

0.537

0.467–0.608

0.295

1.155

0.698

0.449

0.147

 DD + AFP

0.746

0.686–0.805

 < 0.001*

0.652

0.921

0.500

0.421

 DD + free β-hCG

0.743

0.683–0.802

 < 0.001*

0.573

0.937

0.500

0.437

 AFP + free β-hCG

0.553

0.484–0.623

0.136

1.037

0.651

0.485

0.136

 DD + AFP + free β-hCG

0.757

0.700–0.815

 < 0.001*

0.790

0.897

0.537

0.434

PE (53)

 DD

0.767

0.698–0.835

 < 0.001*

0.965

0.849

0.640

0.489

 AFP

0.567

0.471–0.664

0.151

1.205

0.377

0.816

0.194

 Free β-hCG

0.511

0.418–0.604

0.814

0.440

0.113

0.971

0.084

 DD + AFP

0.765

0.698–0.833

 < 0.001*

0.804

0.868

0.618

0.486

 DD + free β-hCG

0.772

0.704–0.840

 < 0.001*

0.947

0.830

0.647

0.477

 AFP + free β-hCG

0.547

0.458–0.637

0.312

0.873

0.792

0.338

0.131

 DD + AFP + free β-hCG

0.788

0.723–0.854

 < 0.001*

0.952

0.849

0.647

0.496

SPE (41)

 DD

0.905

0.862–0.948

 < 0.001*

1.050

1.000

0.713

0.713

 AFP

0.675

0.581–0.768

0.001**

0.910

0.854

0.449

0.302

 Free β-hCG

0.561

0.462–0.659

0.240

0.570

0.951

0.176

0.128

 DD + AFP

 0.904

0.861–0.947

 < 0.001*

0.543

1.000

0.757

0.757

 DD + free β-hCG

0.894

0.848–0.939

 < 0.001*

0.810

0.951

0.765

0.716

 AFP + free β-hCG

0.693

0.603–0.784

 < 0.001*

0.807

0.878

0.441

0.319

 DD + AFP + free β-hCG

0.912

0.897–0.953

 < 0.001*

0.706

1.000

0.757

0.757

HDP = GH + PE + SPE (220)

 DD

0.721

0.663–0.779

 < 0.001*

0.965

0.736

0.640

0.376

 AFP

0.570

0.510–0.631

0.026**

1.105

0.395

0.743

0.138

 Free β-hCG

0.513

0.450–0.575

0.684

1.155

0.632

0.449

0.080

 DD + AFP

0.719

0.662–0.776

 < 0.001*

0.614

0.932

0.404

0.336

 DD + free β-hCG

0.717

0.660–0.774

 < 0.001*

0.492

0.950

0.397

0.347

 AFP + free β-hCG

0.546

0.484–0.607

0.146

0.983

0.668

0.449

0.117

 DD + AFP + free β-hCG

0.736

0.679–0.792

 < 0.001*

1.429

0.709

0.684

0.393

  1. DD D-dimer, AFP alpha-fetoprotein, free β-hCG free beta subumit of human chorionic gonadotropin, MoM multiple of the median, GH gestational hypertension, PE Preeclampsia, SPE severe preeclampsia, HDP Hypertensive disorders of pregnancy, AUC area under curve. *P < 0.001; **P < 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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