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Fig.5 | Journal of Translational Medicine

Fig.5

From: Role of SIK1 in the transition of acute kidney injury into chronic kidney disease

Fig.5

SIK1 regulates WNT/β-catenin pathway in vivo and in vitro. a Western blot analysis of SIK1, WNT1, p-β-catenin (Y654) and nuclear β-catenin protein levels in different groups of mice. b real-time PCR analysis of β-catenin, TCF4 and LEF1 in HK2 cells treated with SIK1 shRNA or Scramble shRNA. c Western blot analysis β-catenin, and p-β-catenin(Y654) in HK2 cells treated with SIK1 shRNA or Scramble shRNA. d Representative immunofluorescence images of β-catenin in HK2 cells. Scale bar = 50 μm. Data are shown as mean ± s.d. *P < 0.05 vs Control, #P < 0.05 vs AA. All experiments were performed in triplicate

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