Fig. 3
From: Role of SIK1 in the transition of acute kidney injury into chronic kidney disease
Overexpression of SIK1 alleviated AA-induced AKI-CKD transition. a The kidney index, Scr, BUN and 24 h urinary protein levels in different groups of mice. b real-time PCR analysis of Caspase 1, and IL-1β mRNA levels in different groups of mice. c HE, PAS and Masson's trichrome staining were used to assess the histological changes and the extent of tubulointerstitial fibrosis. Scale bar = 50 µm. d Representative immunohistochemical staining images of E-cadherin, α-SMA, and COLI protein in different groups of mice. Scale bar = 50 µm. The graphs showed the quantitative analysis of E-cadherin, α-SMA, and COL1 in immunohistochemically stained sections. Data are shown as mean ± s.d. *P< 0.05 vs Control, #P< 0.05 vs AA. All experiments were performed in triplicate