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Table 1 Clinical characteristics of the participants

From: Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults

Characteristic

HC group (n = 73)

MHOO group (n = 72)

MUOO group (n = 72)

pa

Age (years)

44.48 (12.05)

44.39 (12.74)

44.82 (12.72)

0.977

Sex

0.957

 Male

48 (65.75%)

49 (68.06%)

48 (66.67%)

 

 Female

25 (34.25%)

23 (31.94%)

24 (33.33%)

 

BMI (kg/m2)

21.99 (1.50)

27.38 (2.48)**

28.15 (2.71)**

1.85E−42

Metabolic components

 SBP (mmHg)

114.00 (9.38)

122.42 (12.56)**

132.85 (15.65)**,##

2.38E−15

 DBP (mmHg)

69.38 (7.07)

77.51 (10.02)**

83.21 (10.86)**,#

3.02E−15

 TG (mmol/L)

0.92 (0.76–1.12)

1.23 (0.90–1.57)*

2.06 (1.51–2.91)**,##

1.38E−11

 HDL-C (mmol/L)

1.55 (0.30)

1.37 (0.23)**

1.18 (0.33)**,##

9.53E−12

 FBG (mmol/L)

4.96 (4.72–5.26)

5.00 (4.68–5.19)

5.64 (5.07–6.12)**,##

1.52E−9

Biochemical measures

 TC (mmol/L)

4.54 (0.74)

4.57 (0.79)

5.06 (1.09)*,#

0.001

 LDL-C (mmol/L)

2.53 (0.65)

2.62 (0.74)

3.01 (0.91)**,#

0.001

 NEFA (mmol/L)

0.50 (0.20)

0.45 (0.15)

0.46 (0.09)

0.087

 HbA1c (%)

5.40 (5.30–5.60)

5.40 (5.27–5.70)

5.70 (5.50–6.12)**,##

3.64E−7

 ALT (U/L)

15.90 (11.60–21.40)

20.05 (15.38–29.48) **

25.80 (19.32–36.40)**

6.05E−7

 AST (U/L)

19.20 (17.10–22.40)

20.70 (18.38–24.75)

22.55 (19.25–28.15)**

0.001

 Urea (mmol/L)

5.38 (4.27–6.19)

5.31 (4.55–6.00)

5.39 (4.42–5.93)

0.873

 Crea (μmol/L)

60.79 (21.88)

73.28 (17.51)*

70.41 (13.13)*

9.10E−5

 UA (μmol/L)

285.10 (68.52)

319.99 (71.63)*

364.48 (70.57)**,##

7.31E−10

 WBC (× 109)

5.60 (1.53)

6.10 (1.45)*

7.23 (1.70)**,##

6.20E−9

 Neutrophil (× 109)

3.27 (1.17)

3.38 (1.13)

4.32 (1.32)**,##

2.56E−7

 Eosnophils (× 109)

0.08 (0.05–0.17)

0.12 (0.07–0.17)

0.14 (0.08–0.18) *

0.015

Cytokines

 IL-33 (pg/mL)

76.24 (21.42)

80.46 (26.65)

112.11 (36.12)**,##

1.83E−13

 IL-5 (pg/mL)

9.33 (3.71)

10.58 (4.30)

13.28 (4.65)**,##

2.38E−7

 IL-13 (pg/mL)

646.92 (220.21)

741.55 (291.69)*

881.93 (271.69)**,#

1.00E−6

  1. Data are presented as the Mean (SD) or Median (IQR: Q1-Q3) for continuous variables and percentage for categorical variables
  2. HC: healthy control; MHOO: metabolically healthy overweight/obese; MUOO: metabolically unhealthy overweight/obese; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBG: fasting blood glucose; TG: triglycerides; TC: total cholesterol; HDL-C: high-density lipoprotein-cholesterol; LDL-C: low-density lipoprotein-cholesterol; NEFA: non-esterified fatty acids; ALT: Alanine transaminase; AST: aspartate transaminase; Urea: blood urea nitrogen; Crea: creatinine; UA: uric acid; WBC: white blood cell
  3. *p < 0.05, **p < 0.001 compared HC group; #p < 0.05, ##p < 0.001 compared MHOO group
  4. a The One-way ANOVA or Kruskal–Wallis rank sum test or χ2 test were used for comparisons between subgroups
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Journal of Translational Medicine

ISSN: 1479-5876

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