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Table 2 Detection of similar epigenetic markers in blood and in matching primary prostate tumours at a fixed range of assay sensitivity

From: Chromatin conformation changes in peripheral blood can detect prostate cancer and stratify disease risk groups

Markers for category Gene location Category Blood samples Tissue samples Total number of common positive markers Concordance between blood and tissue samples (%)
1 3 Total number of positive markers in blood samples 1 3 Total number of positive markers in tissue samples
Patient A B C D E A B C D E
Markers
3 vs 1 BMP6 PCa.119.37.39 1 1 0 1 1 4 1 1 1 0 1 4 3 60
ERG PCa.119.65.67 1 1 1 1 1 5 1 0 1 0 1 3 3 60
MSR1 PCa.119.77.79 1 0 0 0 1 2 0 0 1 0 1 2 1 20
Common MUC1 PCa.119.121.123 1 1 1 1 0 4 1 1 1 1 1 5 4 80
DAPK1 PCa.119.165.167 1 0 1 1 0 3 0 0 1 0 1 2 1 20
ACAT1 PCa.119.57.59 1 1 1 1 1 5 1 1 1 1 1 5 5 100
3 vs 2 HSD3B2 PCa.119.129.131 1 1 0 1 1 4 1 1 1 0 1 4 3 60
VEGFC PCa.119.205.207 1 1 1 1 1 5 1 1 1 1 1 5 5 100
APAF1 PCa.119.49.51 1 1 1 1 1 5 0 1 1 1 1 4 4 80
  1. When a PCR band of the correct size is detected, it is given a score of 1. When no band is detected, it is given a score of 0
  2. ACAT1: acetyl-CoA acetyltransferase 1; APAF1: apoptotic peptidase activating factor 1; BMP6: bone morphogenetic protein 6; DAPK1: death associated protein kinase 1; ERG: ETS transcription factor ERG; HSD3B2: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; MSR1: macrophage scavenger receptor 1; MUC1: mucin 1, cell surface associated; VEGFC: vascular endothelial growth factor C
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