Table 2 Detection of similar epigenetic markers in blood and in matching primary prostate tumours at a fixed range of assay sensitivity
Markers for category | Gene location | Category | Blood samples | Tissue samples | Total number of common positive markers | Concordance between blood and tissue samples (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 3 | Total number of positive markers in blood samples | 1 | 3 | Total number of positive markers in tissue samples | |||||||||||
Patient | A | B | C | D | E | A | B | C | D | E | ||||||
Markers | ||||||||||||||||
3 vs 1 | BMP6 | PCa.119.37.39 | 1 | 1 | 0 | 1 | 1 | 4 | 1 | 1 | 1 | 0 | 1 | 4 | 3 | 60 |
ERG | PCa.119.65.67 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 0 | 1 | 0 | 1 | 3 | 3 | 60 | |
MSR1 | PCa.119.77.79 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 1 | 2 | 1 | 20 | |
Common | MUC1 | PCa.119.121.123 | 1 | 1 | 1 | 1 | 0 | 4 | 1 | 1 | 1 | 1 | 1 | 5 | 4 | 80 |
DAPK1 | PCa.119.165.167 | 1 | 0 | 1 | 1 | 0 | 3 | 0 | 0 | 1 | 0 | 1 | 2 | 1 | 20 | |
ACAT1 | PCa.119.57.59 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 | 5 | 5 | 100 | |
3 vs 2 | HSD3B2 | PCa.119.129.131 | 1 | 1 | 0 | 1 | 1 | 4 | 1 | 1 | 1 | 0 | 1 | 4 | 3 | 60 |
VEGFC | PCa.119.205.207 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 | 5 | 5 | 100 | |
APAF1 | PCa.119.49.51 | 1 | 1 | 1 | 1 | 1 | 5 | 0 | 1 | 1 | 1 | 1 | 4 | 4 | 80 | |