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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway

Fig. 1

High expression of KPNA2 and CBX8 in BCa is associated with dismal oncological outcomes of patients with BCa. a Venn diagram illustrating DEGs in BCa through microarray dataset GSE3167 and GSE7476 and TCGA database by GEPIA. b The survival curves displaying the correlation between the expression of KPNA2, PCP4, SYNM or FHL1 and survival of patients with BCa. c The PPI networks of KPNA2, PCP4, SYNM and FHL1. The deeper red color suggests higher core degree and the deeper blue color suggests lower core degree. d The box plot of KPNA2 expression in BCa samples (left red box) and normal samples (right grey box) according to GEPIA; *p < 0.05 vs. normal samples. e The correlation analysis between expression of KPNA2 and CBX8 in BCa according to GEPIA (p = 1.6e−06). f The box plot of CBX8 expression in BCa samples (left red box) and normal samples (right grey box) according to GEPIA; *p < 0.05 vs. normal samples. g The expression of KPNA2 and CBX8 in BCa tissues and adjacent non-cancerous tissues determined by RT-qPCR; *p < 0.05 vs. adjacent non-cancerous tissues. h The expression of KPNA2 and CBX8 in BCa tissues and adjacent non-cancerous tissues determined by Western blot analysis; *p < 0.05 vs. adjacent non-cancerous tissues. i The expression of KPNA2 and CBX8 in BCa tissues and adjacent non-cancerous tissues identified by IHC (× 100); *p < 0.05 vs. adjacent non-cancerous tissues. j The correlation between KPNA2 expression and survival condition analyzed by Kaplan–Meier. k The correlation between CBX8 expression and survival condition analyzed by Kaplan–Meier. n = 45. Data comparison between BCa tissues and adjacent non-cancerous tissues was analyzed by paired t-test

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