TY - JOUR AU - Korpela, Sean P. AU - Hinz, Trista K. AU - Oweida, Ayman AU - Kim, Jihye AU - Calhoun, Jacob AU - Ferris, Robert AU - Nemenoff, Raphael A. AU - Karam, Sana D. AU - Clambey, Eric T. AU - Heasley, Lynn E. PY - 2021 DA - 2021/01/23 TI - Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response JO - Journal of Translational Medicine SP - 43 VL - 19 IS - 1 AB - Epidermal growth factor receptor (EGFR) is frequently amplified or overexpressed in head and neck squamous cell carcinoma (HNSCC) and is a clinically validated target for the therapeutic antibody, cetuximab, in the management of this cancer. The degree of response to EGFR inhibitors measured by tumor shrinkage varies widely among HNSCC patients, and the biological mechanisms that underlie therapeutic heterogeneity amongst HNSCC patients remain ill-defined. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-021-02706-8 DO - 10.1186/s12967-021-02706-8 ID - Korpela2021 ER -