Fig. 5

Expression of dermatan sulfate in epidermal and dermal skin. a, c Semi-quantitative analysis. b In HME patients an increase was measured in the extent of GD3A12 (blue) expression in the epidermis after HSD. d No diet-induced changes in expression of LKN1 (blue) could be observed in all groups. Blue represents GD3A12 or LKN1, respectively. Purple represents Ulex Europaeus Agglutinin I (UEA I). LSD, low sodium diet. HSD, high sodium diet. DM1, type 1 diabetes. HME, hereditary multiple exostosis. HC, healthy controls. n = 8 (DM1), n = 7 (HME), n = 12 (HC). *P < 0.05. Data are presented as individual data with mean (SEM). Data were tested with a paired t-test or Wilcoxon test, as appropriate, to compare two diets, and with an unpaired t-test or Kolmogorov–Smirnov test, as appropriate, to compare two patient groups