Fig. 1

Gene expression, correlation and enrichment analysis, showing the significant function related to DEGs. a DEGs were identified from GSE81622 (SLE), GSE81622 (Lupus nephritis), GSE4588(CD4 T Cell), GSE4588(B Cell), GSE50772 and GSE144390 gene expression profiling datasets based on |fold change|≥ 1 and adjusted p value < 0.05. The six datasets share 6 overlapping DEGs. b Heatmap of DEGs derived from integrated analysis. Each circle represents one dataset and each sector represents one gene, the gradual color ranged from white to red represents the changing process of up-regulation. Up-regulated genes were marked in red, respectively. c GO term enrichment analysis of module genes. d Top 5 terms of KEGG analysis in biological pathway category (Ranged by p value). e Corrgrams were derived based on pearson value between DEGs, respectively. f Corrgrams were derived based on pearson value between six datasets, respectively. DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes