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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma

Fig. 4

Potential immune escape mechanisms of each phenotype. a The mRNA expression of molecules potentially involved in priming of innate immunity. The distribution of HRD (b), AS (c), MSI score (d), and TMB (e) in three TIME phenotypes. f, From left to right: mRNA expression (z-score), mutation frequency, amplification frequency, deletion frequency, and expression versus methylation (gene expression correlation with DNA-methylation beta-value) for 62 immunomodulators in the TIME phenotypes. The distribution of CYT value (g), BCR diversity (h), and TCR diversity (i) in three TIME phenotypes. j Regulation of immunomodulators by miRNA. Associations are shown between commonly implicated miRNAs and immunomodulators for each TIME phenotype. All associations shown represent BH-adjusted p-value < 0.05 and Spearman correlation ≤ -0.2; each miRNA included is negatively correlated with a gene for which it is predicted to bind in miRDB. For the boxplot, the asterisks represented the statistical p value (nsP > 0.05, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001). For the heatmap, the asterisks represented the statistical p value (*P < 0.05, **P < 0.01, *** P < 0.001)

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