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Table 5 KEGG pathways enriched for lung metastasis specific genes

From: Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

DEG KEGG pathway FDRa %Genesb (%) #Genesc
Up-regulated JAK-STAT signaling pathway 0.002 7 11
Cell cycle 0.022 5 6
Glycolysis/gluconeogenesis 0.032 6 4
Down-regulated Hematopoietic cell lineage < 0.001 12 12
Cytokine-cytokine receptor interaction < 0.001 7 21
Toll-like receptor signaling pathway < 0.001 11 11
TNF signaling pathway < 0.001 10 11
Leukocyte transendothelial migration 0.001 9 10
NF-kappa B signaling pathway 0.002 9 9
T cell receptor signaling pathway 0.002 9 9
Natural killer cell mediated cytotoxicity 0.006 7 9
B cell receptor signaling pathway 0.006 9 7
Chemokine signaling pathway 0.006 6 11
Complement and coagulation cascades 0.006 8 7
Adherens junction 0.010 8 6
NOD-like receptor signaling pathway 0.012 6 10
Th17 cell differentiation 0.016 7 7
Cell adhesion molecules (CAMs) 0.024 5 8
  1. aThe p-values corrected with Benjamini–Hochberg
  2. bThe percentage of associated genes in each signaling pathway
  3. cThe number of associated genes in each signaling pathway