Table 5 KEGG pathways enriched for lung metastasis specific genes
DEG | KEGG pathway | FDRa | %Genesb (%) | #Genesc |
|---|---|---|---|---|
Up-regulated | JAK-STAT signaling pathway | 0.002 | 7 | 11 |
Cell cycle | 0.022 | 5 | 6 | |
Glycolysis/gluconeogenesis | 0.032 | 6 | 4 | |
Down-regulated | Hematopoietic cell lineage | < 0.001 | 12 | 12 |
Cytokine-cytokine receptor interaction | < 0.001 | 7 | 21 | |
Toll-like receptor signaling pathway | < 0.001 | 11 | 11 | |
TNF signaling pathway | < 0.001 | 10 | 11 | |
Leukocyte transendothelial migration | 0.001 | 9 | 10 | |
NF-kappa B signaling pathway | 0.002 | 9 | 9 | |
T cell receptor signaling pathway | 0.002 | 9 | 9 | |
Natural killer cell mediated cytotoxicity | 0.006 | 7 | 9 | |
B cell receptor signaling pathway | 0.006 | 9 | 7 | |
Chemokine signaling pathway | 0.006 | 6 | 11 | |
Complement and coagulation cascades | 0.006 | 8 | 7 | |
Adherens junction | 0.010 | 8 | 6 | |
NOD-like receptor signaling pathway | 0.012 | 6 | 10 | |
Th17 cell differentiation | 0.016 | 7 | 7 | |
Cell adhesion molecules (CAMs) | 0.024 | 5 | 8 |