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Table 4 KEGG pathways enriched for liver metastasis specific genes

From: Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

DEG

KEGG pathway

FDRa

%Genesb (%)

#Genesc

Up-regulated

Cell cycle

0.036

10

12

FoxO signaling pathway

0.047

7

10

Glucagon signaling pathway

0.048

7

7

Down-regulated

Rap1 signaling pathway

< 0.001

9

19

Bile secretion

 0.001

13

9

PI3K-Akt signaling pathway

 0.001

6

22

Platelet activation

0.002

10

12

MAPK signaling pathway

0.004

6

18

Ras signaling pathway

0.005

6

15

Focal adhesion

0.008

7

13

Complement and coagulation cascades

0.009

9

8

HIF-1 signaling pathway

0.009

8

9

Regulation of actin cytoskeleton

0.012

6

13

ErbB signaling pathway

0.020

8

7

Peroxisome

0.020

8

7

ABC transporters

0.021

11

5

  1. aThe p-values corrected with Benjamini–Hochberg
  2. bThe percentage of associated genes in each signaling pathway
  3. cThe number of associated genes in each signaling pathway