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Table 4 KEGG pathways enriched for liver metastasis specific genes

From: Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites

DEG KEGG pathway FDRa %Genesb (%) #Genesc
Up-regulated Cell cycle 0.036 10 12
FoxO signaling pathway 0.047 7 10
Glucagon signaling pathway 0.048 7 7
Down-regulated Rap1 signaling pathway < 0.001 9 19
Bile secretion  0.001 13 9
PI3K-Akt signaling pathway  0.001 6 22
Platelet activation 0.002 10 12
MAPK signaling pathway 0.004 6 18
Ras signaling pathway 0.005 6 15
Focal adhesion 0.008 7 13
Complement and coagulation cascades 0.009 9 8
HIF-1 signaling pathway 0.009 8 9
Regulation of actin cytoskeleton 0.012 6 13
ErbB signaling pathway 0.020 8 7
Peroxisome 0.020 8 7
ABC transporters 0.021 11 5
  1. aThe p-values corrected with Benjamini–Hochberg
  2. bThe percentage of associated genes in each signaling pathway
  3. cThe number of associated genes in each signaling pathway