Fig. 4

Brain-specific metastasis signature in primary breast tumors. a Hierarchical clustering of 268 primary breast cancer patients was performed with 23 genes in the tight junction pathway. A dendrogram of the tumors is shown on the left, tumors from patients who developed brain metastasis were denoted with asterisk marks; b metastasis-free survival between low- and high-risk groups of primary breast cancer patients distinguished based on the risk score. The p-value of survival difference by logrank test was shown