Table 1 The top five enriched GO terms for cell type-specific disease gene modules
From: An analytical method for the identification of cell type-specific disease gene modules
Cell type | ASD | SCZ | BPD |
|---|---|---|---|
Ast | GO: 0098793 presynapse | GO: 0016358 dendrite development | GO: 0032922 circadian regulation of gene expression |
GO: 0050808 synapse organization | GO: 0050769 positive regulation of neurogenesis | GO: 0007623 circadian rhythm | |
GO: 0010975 regulation of neuron projection development | GO: 0007409 axonogenesis | GO: 0048511 rhythmic process | |
/ | GO: 0010975 regulation of neuron projection development | GO: 0042752 regulation of circadian rhythm | |
/ | GO: 1901214 regulation of neuron death | GO: 0050795 regulation of behavior | |
GABA | GO: 0060078 regulation of postsynaptic membrane potential | GO: 0098982 GABA-ergic synapse | GO: 1902495 transmembrane transporter complex |
GO: 0042391 regulation of membrane potential | GO: 0098793 presynapse | GO: 1990351 transporter complex | |
GO: 0045211 postsynaptic membrane | GO: 0097060 synaptic membrane | GO: 0022824 transmitter-gated ion channel activity | |
GO: 1902495 transmembrane transporter complex | GO: 0045211 postsynaptic membrane | GO: 0022835 transmitter-gated channel activity | |
GO: 1990351 transporter complex | GO: 0060078 regulation of postsynaptic membrane potential | GO: 0005230 extracellular ligand-gated ion channel activity | |
Gluta | GO: 0097060 synaptic membrane | GO: 0097060 synaptic membrane | GO: 0097060 synaptic membrane |
GO: 0045211 postsynaptic membrane | GO: 0045211 postsynaptic membrane | GO: 0045211 postsynaptic membrane | |
GO: 0099572 postsynaptic specialization | GO: 0099572 postsynaptic specialization | GO: 0034702 ion channel complex | |
GO: 0098984 neuron to neuron synapse | GO: 0098978 glutamatergic synapse | GO: 1902495 transmembrane transporter complex | |
GO: 0022839 ion gated channel activity | GO: 0098984 neuron to neuron synapse | GO: 1990351 transporter complex | |
OPC | GO: 0097060 synaptic membrane | GO: 0098978 glutamatergic synapse | GO: 0045211 postsynaptic membrane |
GO: 0045211 postsynaptic membrane | GO: 0051961 negative regulation of nervous system development | GO: 0097060 synaptic membrane | |
GO: 0099572 postsynaptic specialization | GO: 0032279 asymmetric synapse | GO: 0034702 ion channel complex | |
GO: 0098984 neuron to neuron synapse | GO: 0098984 neuron to neuron synapse | GO: 1902495 transmembrane transporter complex | |
GO: 0032279 asymmetric synapse | GO: 0097060 synaptic membrane | GO: 0032279 asymmetric synapse | |
End | GO: 0016570 histone modification | GO: 0030902 hindbrain development | / |
GO: 0016569 covalent chromatin modification | GO: 0005925 focal adhesion | ||
GO: 0045765 regulation of angiogenesis | GO: 0005924 cell-substrate adherens junction | ||
GO: 0033044 regulation of chromosome organization | GO: 0030055 cell-substrate junction | ||
GO: 1901342 regulation of vasculature development | GO: 1903706 regulation of hemopoiesis | ||
Mic | GO: 0016569 covalent chromatin modification | GO: 0050769 positive regulation of neurogenesis | / |
GO: 0016570 histone modification | GO: 0010975 regulation of neuron projection development | ||
GO: 0018205 peptidyl-lysine modification | GO: 0016049 cell growth | ||
GO: 0031056 regulation of histone modification | GO: 0031346 positive regulation of cell projection organization | ||
GO: 1902275 regulation of chromatin organization | GO: 0070997 neuron death | ||
Oli | GO: 0016569 covalent chromatin modification | GO: 0010975 regulation of neuron projection development | / |
GO: 0022604 regulation of cell morphogenesis | GO: 0043025 neuronal cell body | ||
GO: 0010769 regulation of cell morphogenesis involved in differentiation | GO: 0007409 axonogenesis | ||
GO: 0016570 histone modification | GO: 0098793 presynapse | ||
GO: 0022898 regulation of transmembrane transporter activity | GO: 0050769 positive regulation of neurogenesis |