Skip to main content

Table 1 Diagnostic criteria classification with respect to the significance of PEM and other core symptoms

From: The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis

Criteria set ME/CFS Post-exertional malaise inclusion
  Author/institution No PEM (CF) Optional PEM (CFS) Required PEM (ME)
CDC (1988), Holmes definition Holmes 1988 [53], Centers for Disease Control and Prevention, USA   X  
Oxford (1991) Sharpe 1991 [22] X   
CDC (1994), Fukuda definition Fukuda 1994 [23], Centers for Disease Control and Prevention   X  
London (1994) The National Task Force on CFS/PVFS/ME 1994 [54]   Xa  
CCC (2003), Canadian Consensus Criteria for ME/CFS Carruthers 2003 [24]    X
Empirical CDC (2005) Reeves 2005 [55], Centers for Disease Control and Prevention, USA   X  
NICE guideline (2007) Nice 2007 [56], UK’s National Institute for Health and Clinical Excellence   Xb  
Canada-revised (2010) Jason 2010 [57]    X
ME-ICC (2011), International Consensus Criteria for ME Carruthers 2011 [25]    Xc
IOM (2015) (SEID) Institute of Medicine 2015 [1]    X
  1. aRequires exercise-induced fatigue, but does not require presence of all core symptoms;
  2. bNo PEM required (may be post-exertional fatigue) and does not require presence of all core symptoms;
  3. cPost-exertional neuroimmune exhaustion (PENE)