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Table 2 Set of candidate proteins to monitor transcriptionally, which are involved in different hypoxia-dependent phenotypes, leading to mechanical and functional barriers

From: Hypoxia and the phenomenon of immune exclusion

Hypoxic-dependent phenotype

Proteins to monitor (mRNA)

ECM remodeling

ZEB1, ZEB2, MMP2, MMP9, bFGF, IL-6, PDGF, TGF-B, P4AH1, P4AH2, PLOD1, PLOD2, LOX

Metabolism switch

CAIX-XII, LDHA, MCT1, MCT4, SLC2A1, PDK1, ALDA, GLUT 1-3, PKM2

Angiogenesis

VEGFA, SCF, ANGPT2, SDF1, PDGFB, PGF, CTGF, FGF

Stem cell maintenance

ALKBH5, SIAH1, WWTR1, GCLM, BMP, JAK-STAT, SHH, SOX2, Oct-4, NANOG

Immune evasion

PDL1, CD39, CD47, CD73, CXCL12, ET-1, ET-2, SDF1, Sema3A