Fig. 2From: Hypoxia and the phenomenon of immune exclusionHypoxia-induced mechanical barriers. Mechanical barriers represent a category of determinants of immune exclusion where a lack of interaction between T cells and cancer cells is due to physical impediments. Hypoxia induced-mechanical barriers include neoangiogenesis (vascular accessibility), ECM remodeling (stromal fibrosis, collagen remodelling and crosslinking), EMT and cancer cell coatingBack to article page