From: The roles of osteocytes in alveolar bone destruction in periodontitis
Gene | Gene-editing method | Signaling pathway | Bone phenotype(s) | References |
---|---|---|---|---|
β-catenin | Deletion | Wnt/β-catenin signaling | Bone resorption↑, bone mass and density↓ | [14] |
Tnfsf11 | Deletion | RANKL/RANK/OPG system | Bone resorption↓ | [15] |
Csf-1 | Deletion | CSF‐1/Nox4/oxidative stress | Bone formation↓, bone resorption↓ | [16] |
Wnt1 | Deletion | Wnt1-mTOR signaling | Bone formation↓ | [17] |
Pgc-1 | Deletion | AMPK/PGC-1 pathway | Bone volume↓ | [24] |