Skip to main content

Table 1 Specific gene deletion evidences on the role of osteocytes in bone resorption

From: The roles of osteocytes in alveolar bone destruction in periodontitis

Gene

Gene-editing method

Signaling pathway

Bone phenotype(s)

References

β-catenin

Deletion

Wnt/β-catenin signaling

Bone resorption↑, bone mass and density↓

[14]

Tnfsf11

Deletion

RANKL/RANK/OPG system

Bone resorption↓

[15]

Csf-1

Deletion

CSF‐1/Nox4/oxidative stress

Bone formation↓, bone resorption↓

[16]

Wnt1

Deletion

Wnt1-mTOR signaling

Bone formation↓

[17]

Pgc-1

Deletion

AMPK/PGC-1 pathway

Bone volume↓

[24]