Skip to main content

Table 1 Altered cargo of exosomes under hypoxic condition

From: Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implications

Cancer

Breast

Ovarian

Pancreas

Myeloma

Gliablastoma

Prostate

Colorectal

Cell line

MCF7, SKBR3, and MDA-MB 231/ 4T1

SKOV3, HO-8910

BxPC-3 and AsPC-1

RPMI8226, KMS-11, and U266

U87MG

LNCaP and PC3 cells

LNCaP, 22Rv1, PC3, and PWR-1E

HT29 and HCT116

CRC patients

Hypoxic condition

1% O2 and 0.1% O2

1% O2

1% O2

1% O2

1% O2

1% O2

1% O2

Cargo (Increased)

miR-210 [41, 63]

miR-21–3p, miR-125b-5p, and miR-181d-5p [132]

miR-21 [133]

miR-135b [134]

HIF mRNA, LOX, TSP1, VEGF, disintegrin, MMP, and ADAMTS1 [68]

MMPs, IL-8, PDGFs, caveolin 1, and lysyl oxidase [107]

CD63, CD81, HSP90, HSP70, and Annexin II [67]

Triglycerides, omega-6 fatty acids, linoleic acid, arachidonic acid, palmitic acids, stearic acids, and linoleic acids [135]

lactic acid [136]

Wnt4 [137]

miR-210 [108]