Fig. 1From: Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implicationsBiogenesis and secretion of exosomes. Exosomes originate from multivesicular body (MVB) and release into the extracellular matrix upon fusion of MVB with the plasma membrane. One secreted, exosomes can reach to target cells through three possible ways. Microvesicles shed directly from the plasma membrane. N: nucleusBack to article page