Fig. 1

Radiological and cytological features in a representative patient. A. Chest computed tomography at different timepoints. 1. CT images at admission (at 22 months after starting pembrolizumab), showing a COP pattern with multiple pseudo-nodular parenchymal consolidations with irregular and shaded margins, spread bilaterally but more extended to the lower lobes. Ground glass areas were observed in the upper right lobe. 2. CT image at 1 month after the onset of CIP and after i.v. methylprednisolone, showing significant resolution of the bilateral consolidations with minimal resolution of ground-glass opacities. 3. CT image at 4 months after discharge showing further improvement in radiological alterations