From: The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
Factor Pattern | Factor1 | Factor2 | Factor3 | Factor4 |
---|---|---|---|---|
Clinical features and outcomes | ||||
 Body mass index | – | 0.319 | – | – |
 Pneumonia Severity Index | 0.393 | – | – | – |
 SOFA score | 0.571 | – | 0.382 | – |
 ICU length of stay | – | – | 0.333 | 0.686 |
 Mechanical ventilation duration | – | – | 0.331 | 0.70 |
 Hospital length of stay | – | −0.303 | 0.344 | 0.585 |
Biological findings and immune cells | ||||
 PaO2:FiO2 | – | – | – | – |
 Lactate level | 0.675 | – | – | – |
 C-reactive protein | 0.506 | – | – | −0.302 |
 Procalcitonin | 0.579 | – | 0.375 | −0.442 |
 Serum Creatinine | 0.623 | – | 0.318 | −0.344 |
 NT-ProBNP | 0.596 | – | – | – |
 Leukocytes | – | – | −0.644 | – |
 Neutrophils | – | – | −0.622 | – |
 Monocytes | −0.472 | – | −0.322 | −0.317 |
 Lymphocytes | −0.567 | – | – | – |
 CD3 + T Lymphocytes | −0.587 | – | – | – |
 CD4 +/CD8 + T Lymphocytes | – | – | – | – |
 NK cells | – | – | – | – |
Cytokine plasma concentrations | ||||
 sCD40-Ligand | 0.525 | 0.472 | −0.396 | – |
 FLT3L | 0.699 | 0.466 | – | – |
 CX3CL1 | 0.732 | – | – | – |
 G-CSF | 0.553 | 0.316 | – | – |
 GM-CSF | 0.615 | – | – | 0.501 |
 Granzyme B | 0.618 | 0.478 | – | – |
 CXCL1 | 0.534 | – | – | – |
 CXCL2 | 0.432 | – | – | – |
 INF-α | 0.300 | 0.328 | – | 0.308 |
 IL1-α | 0.347 | 0.453 | −0.561 | – |
 IL1-ß | 0.672 | 0.492 | – | – |
 IL1-RA | 0.628 | – | 0.343 | – |
 IL-2 | 0.648 | 0.344 | – | – |
 IL-6 | 0.588 | 0.552 | – | – |
 IL-7 | 0.419 | – | −0.548 | – |
 IL-8 | 0.491 | – | 0.301 | – |
 IL-10 | 0.477 | 0.312 | – | – |
 IL-15 | 0.815 | – | – | – |
 IL-33 | 0.307 | 0.402 | – | – |
 CXCL10 | 0.635 | – | – | 0.35 |
 CCL2 | 0.696 | – | 0.453 | – |
 CCL3 | 0.589 |  | 0.406 | – |
 CCL4 | 0.361 | – | 0.409 | – |
 CCL20 | 0.737 | – | – | – |
 CCL19 | 0.498 | 0.544 | – | – |
 PD-L1 | 0.787 | – | – | – |
 CCL5 | – | 0.318 | −0.582 | – |
 TGF-α | 0.401 | 0.465 | −0.467 | – |
 TNF-α | 0.837 | – | – | – |
 TRAIL | − | – | −0.36 | – |
Cytokine production of blood leukocytes on ex vivo stimulation | ||||
 sCD40-Ligand (WBS) | −0.809 | 0.481 | – | – |
 GM-CSF (WBS) | −0.65 | 0.45 | – | – |
 INF-γ (WBS) | −0.426 | 0.309 | – | – |
 IL1-ß (WBS) | −0.624 | 0.487 | – | – |
 IL-2 (WBS) | −0.609 | 0.414 | – | – |
 IL-4 (WBS) | −0.432 | – | 0.314 | – |
 IL-5 (WBS) | −0.414 | 0.340 | – |  |
 IL-6 (WBS) | −0.671 | 0.565 | – |  |
 IL-10 (WBS) | −0.499 | 0.347 | – |  |
 IL-12 (WBS) | −0.772 | 0.474 | – |  |
 IL-13 (WBS) | −0.686 | 0.414 | – |  |
 IL-15 (WBS) | −0.824 | 0.399 | – |  |
 IL-17A (WBS) | −0.472 | 0.349 | – |  |
 IL-33 (WBS) | −0.805 | 0.485 | – |  |
 TNF-α (WBS) | −0.617 | 0.471 | – |  |