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Table 7 Biological functions of discussed miRs in cancer

From: Systematic review and meta-analysis of the prognostic significance of microRNAs related to metastatic and EMT process among prostate cancer patients

Name of microRNA Genomic locations Biological functions in cancer Ref.
miR-3622a 8p21.1 miR-3622 regulates cancer cells proliferation, progression, apoptosis, G0/G1 cell cycle arrest, migration and invasion abilities of cancer, EMT, metastasis [23, 41,42,43,44]
miR-466 3p23 miR-466 induces proliferation, migration, invasion, angiogenesis cell cycle arrest, apoptosis in cancer cells, EMT and metastasis [25, 45, 46]
miR-543 14q32.31 mir-543 mediates cell proliferation and tumor growth, apoptosis, the cell cycle, migration, invasion, EMT and metastasis [30, 47,48,49,50,51,52,53]
miR-132 17p13.3 miR-132 regulates proliferation of cancer cells, colony formation, tumor growth, migration and invasion of cancer cells, the G1/S phase transition of the cell cycle, EMT in cancer cells, apoptosis in cancer cells [54,55,56,57,58]
miR-212 17p13.3 miR-212 mediates the proliferation and invasion of cancer cells, EMT and metastasis [59,60,61,62]
miR-141-3p 12p13.31 miR-141 regulates proliferation, tumor growth, migration, EMT, chemosensitivity, apoptosis, angiogenesis, oxidative stress response, cellular motility and control “stemness”
miR-141–3p regulates proliferation, tumor growth, migration, and invasion of cancer cells, cancer cell progression, EMT and metastasis
[33, 63,64,65,66,67,68,69,70]
miR-503 Xq26.3 miR-503 regulates cell proliferation, tumor angiogenesis, cell growth and EMT in cancer cells [71,72,73,74,75,76,77]
miR-409-3p 14q32.31 miR-409-3p mediates tumorigenesis, tumor growth, invasion, EMT and metastasis of tumor cells [32, 78,79,80,81]
miR-409-5p 14q32.31 miR-409-5p mediates tumorigenesis, EMT and bone metastasis [32, 81]
miR-301a 17q22 miRNA-301a regulates tumor cell invasion, migration, cell proliferation, apoptosis and enhancing chemosensitivity, EMT and metastasis [82,83,84]
miR-210-3p 11p15.5 miR-210-3p regulates cell survival, stem cell differentiation, angiogenesis, DNA damage repair, mitochondrial metabolism, immune response, EMT and metastasis [28, 63, 85,86,87,88,89]
miR-203 14q32.33 miR-203 regulates tumor proliferation, invasion, migration, apoptosis, EMT and metastasis [90,91,92,93]
miR-573 4p15.2 miR-573 mediates cell proliferation, tumor growth, apoptosis, angiogenesis, EMT and invasion of cancer cells [94,95,96]
miR-802 21q22.12 miR-802 modulates proliferation, tumor growth, apoptosis, migration, invasion, EMT and metastasis of cancer cells [29, 97,98,99,100]
miR-410-3p 14q32.31 miR-410-3p mediates cell proliferation, invasion, migration, EMT, apoptosis, chemosensitivity and autophagy [21, 101,102,103]