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Table 1 Characteristic of CRC patients with or without KRAS mutation

From: Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients

Characteristics

CRC patients

P-value

 

KRAS-mutated (n=101)

KRAS wild-type (n=234)

 

Age

0.61

 [Median (IQR)] (year)

61 (49,68)

59.5 (51.25,67.75)

 

Sex

0.85

 Male

62 (30.5)

141 (69.5)

 

 Female

39 (29.5)

93 (70.5)

 

Primary site

0.19

 Rectum

49 (33.8)

96 (66.2)

 

 Left colon

22 (23.2)

73 (76.8)

 

 Transverse colon

11 (40.7)

16 (59.3)

 

 Right colon

19 (27.9)

49 (72.1)

 

Pathological T classification

0.36

 T1-2

 15 (36.6)

26 (63.4)

 

 T3-4

86 (29.7)

204 (70.3)

 

Pathological N classification

0.95

 N0

53 (30.5)

121 (69.5)

 

 N1-2

44 (30.8)

99 (69.2)

 

M classification

0.02*

 M0

83 (43.5)

108 (56.5)

 

 M1

18 (27.3)

48 (72.7)

 

Pathological stage

0.85

 I-II

47 (30.5)

107 (69.5)

 

 III-IV

52 (31.5)

113 (68.5)

 

Leukocyte (109/L)

6.70±2.16

6.85±2.60

0.614

Blood platelet (109/L)

283.94±99.25

292.55±108.71

0.495

Neutrophil (109/L)

3.82±2.24

4.36±3.53

0.157

Lymphocyte (109/L)

1.63±0.61

1.79±1.37

0.260

Albumin (g/L)

18.73±10.46

22.76±28.45

0.167

Total T lymphocyte (%)

65.77±9.76

65.58±1034

0.877

Helper T lymphocyte (%)

40.00±7.34

39.13±8.68

0.374

Suppressor t lymphocyte (%)

20.38±.82

20.67±7.27

0.739

Natural killer cell (%)

14.17±8.01

14.04±7.31

0.888

B-lymphocyte (%)

12.48±5.71

11.96±7.25

0.518

Immunoglobulin G (g/L)

11.86±3.12

11.54±2.98

0.369

Immunoglobulin M (g/L)

0.91±0.40

1.08±0.94

0.024*

Immunoglobulin A (g/L)

2.51±1.18

2.44±0.98

0.617

Complement C3 (g/L)

0.95±0.20

0.99±0.24

0.134

Complement C4 (g/L)

0.25±0.09

0.25±0.10

0.909

CRP (mg/L)

7.07±9.20

10.61±18.43

0.020*

hs-CRP (mg/L)

1.60±2.19

2.43±4.33

0.020*

  1. *P<0.05 CRP C-reactive protein, hs-CRP high-sensitivity C-reactive protein