Table 2 Comparisons of PD-L1 expression, CD4 and CD8 density between primary tumor and liver metastasis
Groups | PD-L1 CPS (median) | P value | CD4 density (%, median) | P value | CD8 density (%, median) | P value | |||
|---|---|---|---|---|---|---|---|---|---|
Primary tumor | Liver metastasis | Primary tumor | Liver metastasis | Primary tumor | Liver metastasis | ||||
General | 0.5 | 1.0 | 0.10 | 7.0 | 12.0 | 0.003* | 4.5 | 3.5 | 0.63 |
Pre-operative che-mo/radiotherapy for primary tumor | |||||||||
 No | 1.0 | 1.0 | 0.09 | 7.5 | 12.5 | 0.01* | 4.0 | 5.0 | 0.78 |
 Yes | 0.0 | 0.0 | 0.31 | 5.5 | 7.5 | 0.28 | 5.0 | 1.5 | 0.03* |
Tumor differentiation | |||||||||
 Poor | 0.0 | 0.0 | 0.63 | 5.5 | 3.0 | 0.68 | 10.0 | 1.5 | 0.07 |
 Moderate | 0.5 | 1.0 | 0.052 | 7.5 | 15.0 | 0.003* | 3.0 | 4.0 | 0.70 |
Primary tumor site | |||||||||
 Colon | 0.0 | 0.0 | 0.27 | 5.3 | 10.0 | 0.03* | 2.0 | 2.5 | 0.47 |
 Rectum | 1.5 | 1.3 | 0.20 | 10.0 | 17.5 | 0.04* | 5.0 | 5.0 | 0.95 |
Metastatic time model | |||||||||
 Concurrent | 0.0 | 1.0 | 0.05* | 7.5 | 12.5 | 0.01* | 5.0 | 3.5 | 0.95 |
 Metachronous | 1.5 | 1.0 | 0.22 | 3.0 | 5.0 | 0.22 | 2.0 | 4.0 | 0.32 |
Resection time model | |||||||||
 Concurrent | 0.0 | 1.0 | 0.04* | 8.8 | 15.0 | 0.01* | 5.0 | 3.5 | 0.81 |
 Metachronous | 1.3 | 0.8 | 0.13 | 5.0 | 5.8 | 0.23 | 3.3 | 3.3 | 0.12 |