Skip to main content

Table 4 Effect of GW9662 or CH223191 antagonism on LMWF5A drug potency

From: LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Antagonist (pathway)

Cytokine

Mean REP ± STD (95% CI)

REP 1 (95% CI)

REP 2 (95% CI)

REP 3 (95% CI)

GW9662 (PPAR)

TNFα

0.74 ± 0.05 (0.69–0.80)

0.77 (0.67–0.88)

0.69 (0.63–0.75)

0.77 (0.68–0.88)

IL-1β

0.63 ± 0.14 (0.48–0.80)

0.51 (0.40–0.63)

0.61 (0.48–0.74)

0.79 (0.69–0.90)

CH223191 (AhR)

TNFα

0.76 ± 0.09 (0.67–0.86)

0.68 (0.57–0.78)

0.85 (0.77–0.93)

0.76 (0.67–0.86)

IL-1β

0.72 ± 0.09 (0.62–0.82)

0.80 (0.67–0.94)

0.74 (0.58–0.82)

0.62 (0.53–0.70)

  1. Data are presented as mean REP ± STD and 95% CI of three independent experiments