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Table 4 Effect of GW9662 or CH223191 antagonism on LMWF5A drug potency

From: LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Antagonist (pathway) Cytokine Mean REP ± STD (95% CI) REP 1 (95% CI) REP 2 (95% CI) REP 3 (95% CI)
GW9662 (PPAR) TNFα 0.74 ± 0.05 (0.69–0.80) 0.77 (0.67–0.88) 0.69 (0.63–0.75) 0.77 (0.68–0.88)
IL-1β 0.63 ± 0.14 (0.48–0.80) 0.51 (0.40–0.63) 0.61 (0.48–0.74) 0.79 (0.69–0.90)
CH223191 (AhR) TNFα 0.76 ± 0.09 (0.67–0.86) 0.68 (0.57–0.78) 0.85 (0.77–0.93) 0.76 (0.67–0.86)
IL-1β 0.72 ± 0.09 (0.62–0.82) 0.80 (0.67–0.94) 0.74 (0.58–0.82) 0.62 (0.53–0.70)
  1. Data are presented as mean REP ± STD and 95% CI of three independent experiments