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Table 2 Enrichr gene enrichment analysis of the LMWF5A-reduced cytokine signature using Wikipathways, Biocarta, and Elsevier libraries

From: LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Index Name P-value
Wikipathways 2019 human   
1 Toll-like Receptor Signaling Pathway WP75 7.81E−17
2 Regulation of toll-like receptor signaling pathway WP1449 6.72E−16
3 Allograft Rejection WP2328 4.56E−14
4 Development and heterogeneity of the ILC family WP3893 1.88E−10
5 Aryl Hydrocarbon Receptor Pathway WP2873 8.53E−10
6 Cytokines and Inflammatory Response WP530 6.80E−08
7 Resistin as a regulator of inflammation WP4481 1.43E−07
8 Fibrin Complement Receptor 3 Signaling Pathway WP4136 2.03E−07
9 Type II interferon signaling (IFNG) WP619 2.03E−07
10 Lung fibrosis WP3624 1.03E−06
Biocarta 2016   
1 NO2-dependent IL 12 Pathway in NK cells Homo sapiens h no2il12Pathway M6231 3.78E−06
2 IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Homo sapiens h IL12Pathway M4319 1.10E−05
3 NFkB activation by Nontypeable Hemophilus influenzae Homo sapiens h nthiPathway M2821 4.24E−05
4 Signal transduction through IL1R Homo sapiens h il1rPathway M12095 6.58E−05
5 Visceral Fat Deposits and the Metabolic Syndrome Homo sapiens h vobesityPathway M22017 2.80E−03
6 SODD/TNFR1 Signaling Pathway Homo sapiens h soddPathway M2699 3.15E−03
7 IL-10 Anti-inflammatory Signaling Pathway Homo sapiens h il10Pathway M6778 4.54E−03
8 Stress Induction of HSP Regulation Homo sapiens h hsp27Pathway M2587 4.89E−03
9 Cadmium induces DNA synthesis and proliferation in macrophages Homo sapiens h cdMacPathway M4388 5.59E−03
10 TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway M3618 5.94E−03
Elsevier   
1 Macrophage M1 Lineage 1.42E−15
2 Proteins Involved in Psoriasis 3.54E−15
3 IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis 6.74E−15
4 Toll-like Receptors in beta-Cell 1.08E−12
5 CCR1 Expression Targets 9.19E−11
6 Nociception Expression Targets Signaling 3.62E−10
7 Toll-like Receptors Act through MYD88-TIRAP Signaling 5.29E−10
8 Dendritic Cells Function in Psoriasis 6.45E−10
9 Dendritic Cell Function in Ulcerative Colitis 8.53E−10
10 Hashimoto's Thyroiditis 1.31E−09