Table 2 Enrichr gene enrichment analysis of the LMWF5A-reduced cytokine signature using Wikipathways, Biocarta, and Elsevier libraries

Wikipathways 2019 human

1

Toll-like Receptor Signaling Pathway WP75

7.81E−17

2

Regulation of toll-like receptor signaling pathway WP1449

6.72E−16

3

Allograft Rejection WP2328

4.56E−14

4

Development and heterogeneity of the ILC family WP3893

1.88E−10

5

Aryl Hydrocarbon Receptor Pathway WP2873

8.53E−10

6

Cytokines and Inflammatory Response WP530

6.80E−08

7

Resistin as a regulator of inflammation WP4481

1.43E−07

8

Fibrin Complement Receptor 3 Signaling Pathway WP4136

2.03E−07

9

Type II interferon signaling (IFNG) WP619

2.03E−07

10

Lung fibrosis WP3624

1.03E−06

Biocarta 2016

1

NO2-dependent IL 12 Pathway in NK cells Homo sapiens h no2il12Pathway M6231

3.78E−06

2

IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Homo sapiens h IL12Pathway M4319

1.10E−05

3

NFkB activation by Nontypeable Hemophilus influenzae Homo sapiens h nthiPathway M2821

4.24E−05

4

Signal transduction through IL1R Homo sapiens h il1rPathway M12095

6.58E−05

5

Visceral Fat Deposits and the Metabolic Syndrome Homo sapiens h vobesityPathway M22017

2.80E−03

6

SODD/TNFR1 Signaling Pathway Homo sapiens h soddPathway M2699

3.15E−03

7

IL-10 Anti-inflammatory Signaling Pathway Homo sapiens h il10Pathway M6778

4.54E−03

8

Stress Induction of HSP Regulation Homo sapiens h hsp27Pathway M2587

4.89E−03

9

Cadmium induces DNA synthesis and proliferation in macrophages Homo sapiens h cdMacPathway M4388

5.59E−03

10

TNFR1 Signaling Pathway Homo sapiens h tnfr1Pathway M3618

5.94E−03

Elsevier

1

Macrophage M1 Lineage

1.42E−15

2

Proteins Involved in Psoriasis

3.54E−15

3

IL6/IL12 Signaling Activates Immune System in Multiple Sclerosis

6.74E−15

4

Toll-like Receptors in beta-Cell

1.08E−12

5

CCR1 Expression Targets

9.19E−11

6

Nociception Expression Targets Signaling

3.62E−10

7

Toll-like Receptors Act through MYD88-TIRAP Signaling

5.29E−10

8

Dendritic Cells Function in Psoriasis

6.45E−10

9

Dendritic Cell Function in Ulcerative Colitis

8.53E−10

10

Hashimoto's Thyroiditis

1.31E−09