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Table 1 Pro-inflammatory cytokines and chemokines significantly suppressed by LMWF5A in LPS-stimulated PBMC

From: LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Cytokine/chemokine

Gene symbol

Fold change

C-X-C motif chemokine ligand 9

CXCL9

0.48 ± 0.01

C-X-C motif chemokine ligand 10

CXCL10

0.36 ± 0.15

C-X-C motif chemokine ligand 11

CXCL11

0.58 ± 0.08

Interleukin 1 beta

IL1β

0.71 ± 0.05

Interleukin 12 p40 and p70

IL12A and B

0.34 ± 0.07

Tumor necrosis factor alpha

TNFA

0.62 ± 0.07

  1. PBMC were exposed to saline or LMWF5A and then stimulated with 100 ng/ml LPS for 24 h. Cytokine release was determined by ELISA array, and data are presented as fold change (OD ± STD, n = 3, p-value =  ≤ 0.05)
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Journal of Translational Medicine

ISSN: 1479-5876

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