Skip to main content
Fig. 5 | Journal of Translational Medicine

Fig. 5

From: LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC

Fig. 5

LMWF5A mechanisms of action. The activation of JAK/STAT as well as both canonical and non-canonical NF-κB signaling pathways leads to the secretion of inflammatory M1 and Th1 cytokines associated with inflammatory disease and tissue damage. Treatment with LMWF5A results in the activation of PPARγ and AhR, which may repress STAT and NF-κB transcriptional activity. In addition, LMWF5A activates RAP-1 small GTPase, which aids in reducing RhoA GTPase activity and promotes f-actin cytoskeletal rearrangements that enhance endothelial barrier function. Together, these mechanisms of actions may reduce leukocyte extravasation and impede M1 polarization to restore hemostasis in chronic settings

Back to article page