Fig. 4

Representative TNFα and IL-1β % inhibition REP bioassays for antagonist-treated reference drug material. Dose responses in % inhibition TNFα release (a and b) or IL-1β release (c and d) for diluent control-treated reference LMWF5A and 0.5 µM GW9662 PPARγ antagonist-treated reference LMWF5A (a and c) or 0.05 µM CH223191 AhR antagonist-treated reference LMWF5A (b and d). Blue = Reference drug material dose response, Green = Antagonist-treated reference drug material dose response