Fig. 6

Transcriptome differences between healthy and periodontitis. a The protein–protein interaction network of significantly differentially expressed genes between healthy and periodontitis. The node size means the absolute value of logFC, the node with yellow frame means the hub genes with a high connective degree in the network, the red nodes mean the genes up-regulated in periodontitis and blue nodes mean the genes down-regulated in periodontitis. b–e Gene-set enrichment analysis from four aspects (including immunologic signatures, hallmark gene sets, GO biological processes and canonical pathways) revealed the underlying biomolecular differences between healthy and periodontitis