Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review

Table 3 Reported cytokines in the included studies including the effect of Aza/DAC on the reported cytokines

Author first, last, year, journal		mϕ/monocytes	Th1			Th2			Th17			Treg
	Disease	IL-1β	IL-12	IFN-γ	TNF-α	IL-4	IL-5	IL-13	TGF-β	IL-6	IL-17	IL-10
Ehx,Baron 2017 OncoImmunology	GvHD			↓	↓						Equal
Wang, Shi, 2016, JCI Insight	Diabetes	↓			↓					↓
Gao, Mu, 2019, Stem Cell Research and Therapy	Diabetes	Equal			Equal	Equal				Equal		Equal
Chen, Dong, 2019, Kidney International	Diabetes				↓
Cao, Xua, 2014, Endocrinology	Atherosclerosis	↓			↓					↓
Li, Tang, 2016, The American Physiological Society	Biliary arthresia										↓
Li, Tsokos, 2018, JCI Insight	SE			*	*					*	*	*
Huang, Wang, 2016, Biomedicine & Pharmacotherapy	ARDS	↓			↓
Cui, Shang, 2019, Laboratory Investigation	ARDS	↓			↓					↓		↑
Thangavel, Rajasingh, 2014, Am Journal of Pathology	ARDS				↑
Thangavel, Rajasingh, 2015, Journal of Cell Science	ARDS	Equal			Equal					Equal		Equal
Wu, Kuo, 2012, Allergy and Immunology	Asthma					↓	↓	↓				↓
Brand, Renz, 2011, Journal of Allergy and Clinical Immunology	Asthma			↑		↓	↓	↓
Chan, Wu, 2014, Molecular medicine	MS			↓							↓
Wang X, Tao, 2017, Oncotarget	MS	↓	↓	↓	↓					↓	↓
Mangano, Nicoletti, 2014, Journal of Cellular Physiology	MS			Equal					Equal		↓	Equal
Fagone, Nicoletti, 2018, Journal of Neuroimmunology	GBS			↓	↓					↓	↓

In this table no differentiation is made between units (e.g. percentage, ng/ml or counts/mm). Different techniques (e.g. FACS, IHC, ELISA) were used
*Cytokines not compared to non-treated control. Targeted delivery lowers cytokines compared to empty nlg