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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size

Fig. 5

PDGFRα/EGFR signaling activation and effects on RAS/MAPK pathway. SHP2 (PTPN11): Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2; Src: Non-Receptor Tyrosine Kinase; Shc: Src Homology 2 Domain-Containing-Transforming Protein, Grb2: growth factor receptor-bound protein 2, SOS1: Son of sevenless homolog 1, RAS: Rat sarcoma, RAF: rapidly accelerated fibrosarcoma, MEK: mitogen-activated protein kinase kinase, ERK: extracellular signal-regulated kinases, Gli1: GLI Family Zinc Finger 1, EGF: epidermal growth factor, TGFα: transforming growth factor alpha, PDGFAA/AB/BB/CC: platelet derived growth factor AA/AB/BB/CC

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