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Table 1 Clinicopathological variables and their relation to ccRCC progression

From: Combining epigenetic and clinicopathological variables improves specificity in prognostic prediction in clear cell renal cell carcinoma

Variable

M0-PF n = 58

M0-P n = 20

M1 n = 28

M0-PF vs M0-P p-value

M0-PF vs M1 p-value

M0-P vs M1 p-value

Gender

 Male

32

10

21

0.888

0.125

0.139

 Female

26

10

7

   

Morphological gradea

 G1

12

1

0

0.002

 < 0.001

0.394

 G2

30

6

7

   

 G3

15

8

8

   

 G4

1

5

12

   

TNM

 I

39

5

0

 < 0.001

 < 0.001

 < 0.001

 II

10

2

0

   

 III

9

13

0

   

 IV

0

0

28

   

Mayo

 Low

29

3

 

0.006

 Intermediate/high

29

17

    

 Age (years)

65.6 (11.6)

64.2 (11.9)

63.0 (11.0)

0.590

0.345

0.706

 Albumin (g/L)

40.6 (4.1)

38.6 (7.2)

36.7 (4.5)

0.299

 < 0.001

0.121

 Alkaline phosphatase (µkat/L)b

1.9 (2.0)

2.2 (1.5)

5.1 (6.6)

0.745

 < 0.001

0.026

 Calcium (mmol/L)c

2.35 (0.14)

2.32 (0.13)

2.46 (0.26)

0.358

0.212

0.129

 Creatinine (µmol/L)

79.6 (16.3)

86.0 (32.4)

93.3 (27.6)

0.837

0.015

0.300

 Gamma glutamyltanseferase (µkat/L)d

0.76 (1.17)

0.83 (1.21)

2.23 (3.06)

0.401

 < 0.001

0.002

 Hemoglobin (g/L)

137.6 (17.3)

121.1 (22.0)

116.9 (19.1)

0.002

 < 0.001

0.331

 Thromobocyte particle count (109/L)

251.7 (77.7)

316.5 (175.4)

365.3 (136.8)

0.112

 < 0.001

0.090

 Tumor diameter (mm)

56.5 (31.2)

95.0 (44.8)

108.3 (35.7)

 < 0.001

 < 0.001

0.262

  1. Mean values and standard deviation (SD) are reported for each continuous variable. Chi-square tests were used for testing independence between categorical variables and Mann–Whitney U tests were used for comparisons between continuous variables. M0 and M1 denote non-metastatic and metastatic patients at diagnosis respectively, while PF and P denote progress free patients and patients with progress within 5 years respectively
  2. aOne missing value in group M1
  3. bThree missing values. One value is missing in each of M0-PF, M0-P and M1
  4. cOne missing value in M0-PF
  5. dFour missing values. Three in M0-PF and one in M1