Table 4 RCTs with pharmacological and nonpharmacological combined interventions

Fluoxetine + graded exercise [70]

Exercise + fluoxetine: 33

Exercise + placebo: 34

Appointment + fluoxetine: 35

Appointment + placebo: 34

24

20 mg/day

Chalder scale

Graded exercise

P < 0.05

Dialyzable leukocyte extract (DLE) + CBT [71]

DLE + CBT: 20

DLE + clinic: 26

Placebo + CBT: 21

Placebo + clinic: 23

28

5 × 10⁸ leukocytes

8 times biweekly

VAS (global well-being)

Not significant