Fig. 6

DIPG pre-clinical model emulates intact blood–brain barrier (BBB). T1 contrast enhanced images to evaluate an intact BBB. Gadolinium contrast was injected via tail vein. From left to right, these images were taken pre-contrast, 10 min, and 20 min post contrast injection, respectively. All three images look fairly similar without evidence of increased contrast enhancement in the 10 min and 20 min post contrast images. White arrows depict contrast-enhancement in the eye region and brain vasculature. This supports the presence of an intact BBB, making this an ideal DIPG mouse model