Fig. 4
From: OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma
Experimental schema. Day 0 was the day of surgical implantation of patient derived DIPG cells into the fourth ventricle of immunocompromised NOD/SCID mice. Morphological imaging using FLAIR MRI was initiated on day 14 after surgical implantation. MR imaging was continued weekly until termination. Treatment with either OKN-007 or LDN-193189 was initiated on day 28. All treatments were continued for a total of 28Â days, with day 56 being the last day of treatments. All mice were euthanized on day 57 when whole brains were extracted for IHC analysis