Fig. 2

OKN-007 and LDN-193189 both decrease final tumor volumes in a pre-clinical model for DIPG. DIPG final tumor volumes at the completion of treatment. Tumor volumes were computed with additive ROI’s from each slice using FLAIR imaging. a, b Note the highlighted tumor burden in individual slices for the untreated mice. Figure 1b highlights the potential for leptomeningeal spread to the frontal lobe in this untreated mouse. Tumor burden was visibly reduced in c OKN-007 treated, and d LDN-193189 treated mice. e The final tumor burden in the untreated mice (closed circles; n = 4) was significantly higher than mice treated with both OKN-007 (open squares; n = 4) and LDN-193189 (closed triangles; n = 5). There was no significant difference in final tumor volumes between the two treatment arms. An ANOVA (one-way ANOVA, multiple comparisons) statistical test was used. *p < 0.05 and **p < 0.01