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Fig. 10 | Journal of Translational Medicine

Fig. 10

From: OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma

Fig. 10

OKN-007 decreases micro-vessel density (MVD) better than LDN-193189 in a DIPG model. IHC analysis staining for CD34 expression, a marker for MVD. a The ROI’s for data analysis of IHC were placed in the heavily stained regions of the pons as circled in red. b CD34 expression was significantly higher in the untreated mice compared to both treatment arms when using ANOVA multivariate testing. There was also a significant decrease in CD34 expression in the OKN-007 treated mice compared to LDN-193189 treated mice, when using a t-test for statistical analysis. Sample legend: Untreated (UT)—closed circles (n = 4); OKN-007 (OKN)—open squares (n = 4); and LDN-193189 (LDN)—closed triangles (n-5). An ANOVA (one-way ANOVA, multiple comparisons) statistical test was used. *p < 0.05 and **p < 0.01. c The 20× view of IHC slides visibly show increased microvascular density in the untreated mice compared to the d OKN-007 treated and e LDN-193189 treated mice. The scale bar in each image frame is 100 µm

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