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Table 2 Differential expression of in- and decreased circulating inflammatory proteins when comparing QFS to HC, CFS to HC, and QFS to CFS

From: Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome

A

Protein

Coefficient

Std. error

P value

FDR

QFS versus HC

Increased

 4E.BP1

1.4844

0.1848

9.60E−16

6.24E−14

 CD40

0.5412

0.1025

1.30E−07

4.22E−06

 AXIN1

0.9512

0.2358

5.51E−05

8.95E−04

Decreased

 MMP.1

− 1.1973

0.2414

7.09E−07

1.54E−05

 ST1A1

− 0.9150

0.2387

1.26E−04

1.64E−03

B

Protein

Coefficient

Std. error

P value

FDR

CFS versus HC

Increased

 X4E.BP1

1.3171

0.2502

1.41E−07

4.54E−06

 AXIN1

1.0072

0.2904

0.0005

0.0038

Decreased

 MMP.1

− 1.3036

0.2207

3.51E−09

2.28E-07

 LIF.R

− 0.3294

0.0635

2.10E−07

4.54E-06

 MCP.1

− 0.3929

0.0896

1.17E−05

0.0002

 CCL25

− 0.5710

0.1401

4.58E−05

0.0006

 Flt3L

− 0.3485

0.0877

7.03E−05

0.0008

 MCP.4

− 0.5425

0.1408

0.0001

0.0011

 SCF

− 0.3889

0.1029

0.0002

0.0013

 FGF.19

− 0.6764

0.2009

0.0008

0.0047

 CCL11

− 0.3501

0.1044

0.0008

0.0047

 CXCL11

− 0.5295

0.1625

0.0011

0.0061

 DNER

− 0.2270

0.0704

0.0013

0.0063

 CXCL9

− 0.5179

0.1622

0.0014

0.0065

 LAP.TGF.beta.1

− 0.2959

0.1003

0.0032

0.0138

 TRANCE

− 0.4552

0.1557

0.0035

0.0141

 CXCL1

− 0.6282

0.2218

0.0046

0.0177

 TWEAK

− 0.2665

0.0992

0.0072

0.0256

 CX3CL1

− 0.2371

0.0890

0.0077

0.0256

 CXCL5

− 0.8374

0.3152

0.0079

0.0256

 ST1A1

− 0.5975

0.2266

0.0084

0.0256

 MCP.2

− 0.3425

0.1304

0.0086

0.0256

 HGF

− 0.2286

0.0882

0.0096

0.0267

 OSM

− 0.4414

0.1710

0.0098

0.0267

 IL7

− 0.3355

0.1389

0.0157

0.0392

 CXCL6

− 0.4310

0.1784

0.0157

0.0392

 CST5

− 0.2759

0.1176

0.0190

0.0456

C

Protein

Coefficient

Std. error

P value

FDR

QFS versus CFS

Increased

 IL8

0.3432

0.1319

0.0093

0.1945

 CD244

0.2973

0.1112

0.0075

0.1945

 CXCL11

0.5682

0.2261

0.0120

0.1945

 CCL11

0.3821

0.1330

0.0041

0.1945

 LIF.R

0.1770

0.0787

0.0245

0.2355

 CD40

0.3009

0.1378

0.0290

0.2355

 CCL25

0.3994

0.1819

0.0281

0.2355

 CD8A

0.3177

0.1501

0.0343

0.2477

 IL.10RB

0.2368

0.1191

0.0467

0.2683

Decreased

 ST1A1

− 0.6707

0.2828

0.0177

0.2303

  1. In- and decreased inflammatory proteins when comparing (A) QFS (n = 31) to HC (n = 50), (B) CFS (n = 50) to HC (n = 50), and (C) QFS (n = 31) to CFS (n = 50). Results are depicted as a coefficient with Std. Error and FDR. Only proteins that are significantly in- or decreased are depicted and statistical significance was attained if P ≤ 0.05
  2. QFS Q fever fatigue syndrome, HC healthy controls, CFS chronic fatigue syndrome, Std. error standard error, FDR false discovery rate
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Journal of Translational Medicine

ISSN: 1479-5876

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