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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases

Fig. 6

Results of a systems biology analysis of the selected lncRNAs to identify the associated functional biological mechanisms. A network propagation algorithm was initiated from each of the six lncRNAs in a combined heterogeneous lncRNA-gene network to quantitatively prioritize the genes that are expected to be regulated by the given lncRNA. Then, based on the prioritized target genes, gene set enrichment analysis (GSEA) was performed to identify the functionally relevant pathways and Gene Ontology terms. For further details of the method, see the Additional file 15. The color of the dots indicates the statistical significance of the enrichment and the size of the dots indicates the normalized enrichment score for the enriched term in case of the predicted targets of a given lncRNA. FDR: false discovery rate, NES: normalized enrichment score

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