Characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
---|---|---|---|---|
DOB | 25/05/2018 | 25/05/2018 | 01/08/2018 | 07/07/2018 |
Gestational age at birth, weeks | 24 (+ 5 days) | 24 (+ 5 days) | 34 | 28 |
Birth weight (grams) | 720 | 650 | 2400 | 1400 |
Sex | Female | Female | Male | Female |
Prenatal steroids used | Yes | Yes | No | No |
Pulmonary hypertension | Yes | Yes | No | Yes |
Mechanical ventilation duration before transplantation | 3.5 months | 4.5 months | 1 month | 3 months |
PaCO2 level (mmhg) before transplantation | 37.9 | 68 | 59 | 38.6 |
HCO3– (mmHg) before transplantation | 29.1 | 41.3 | 47.2 | 29.5 |
Oxygen support before transplantation | Nasal cannula 0.5 l/min | Nasal cannula 1.0 l/min | Nasal cannula 1.0 l/min | Nasal cannula 0.5 l/min |
PaCO2 at 6 months | 38 | 32.8 | 28.6 | 39.8 |
SpO2 (%) FiO2 (21%) before transplantation | 75 | 91 | 70 | 91 |
SpO2 at 6 months | 100 | 95 | 99 | 97 |
SpO2 at 12 months | 100 | 100 | 100 | 97 |
Postnatal age at UC-MSC administration, days | 144 | 151 | 173 | 160 |
Weight at UC-MSC administration (grams) | 3600 | 4000 | 5400 | 3800 |
Duration from birth to discharge (days) | 161 | 161 | 183 | 173 |
Duration from transplantation to independence from oxygen support | 3 days after the 2nd transplantation | 2 months | 2 months | 4 days after the first transplantation |
Chest X-ray before transplantation | Diffuse fibrosis, atelectasis, diffuse haziness | Diffuse fibrosis, atelectasis, diffuse haziness | Air trapping, diffuse fibrosis, atelectasis, diffuse haziness | Air trapping, diffuse fibrosis, atelectasis, diffuse haziness |
Chest X-ray 12 months after transplantation | Reduction in fibrosis | Reduction in fibrosis | Normal | Normal |