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Table 1 General characterization of patients enrolled in the study

From: Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants

Characteristics

Patient 1

Patient 2

Patient 3

Patient 4

DOB

25/05/2018

25/05/2018

01/08/2018

07/07/2018

Gestational age at birth, weeks

24 (+ 5 days)

24 (+ 5 days)

34

28

Birth weight (grams)

720

650

2400

1400

Sex

Female

Female

Male

Female

Prenatal steroids used

Yes

Yes

No

No

Pulmonary hypertension

Yes

Yes

No

Yes

Mechanical ventilation duration before transplantation

3.5 months

4.5 months

1 month

3 months

PaCO2 level (mmhg) before transplantation

37.9

68

59

38.6

HCO3– (mmHg) before transplantation

29.1

41.3

47.2

29.5

Oxygen support before transplantation

Nasal cannula 0.5 l/min

Nasal cannula 1.0 l/min

Nasal cannula 1.0 l/min

Nasal cannula 0.5 l/min

PaCO2 at 6 months

38

32.8

28.6

39.8

SpO2 (%) FiO2 (21%) before transplantation

75

91

70

91

SpO2 at 6 months

100

95

99

97

SpO2 at 12 months

100

100

100

97

Postnatal age at UC-MSC administration, days

144

151

173

160

Weight at UC-MSC administration (grams)

3600

4000

5400

3800

Duration from birth to discharge (days)

161

161

183

173

Duration from transplantation to independence from oxygen support

3 days after the 2nd transplantation

2 months

2 months

4 days after the first transplantation

Chest X-ray before transplantation

Diffuse fibrosis, atelectasis, diffuse haziness

Diffuse fibrosis, atelectasis, diffuse haziness

Air trapping, diffuse fibrosis, atelectasis, diffuse haziness

Air trapping, diffuse fibrosis, atelectasis, diffuse haziness

Chest X-ray 12 months after transplantation

Reduction in fibrosis

Reduction in fibrosis

Normal

Normal