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Table 3 Contractile parameters of isolated cardiomyocytes

From: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy

 

CON (n = 4)

D-CON (n = 4)

BB (n = 4)

ACEI (n = 4)

AA (n = 4)

Fmax (kN/m2)

15.59 ± 0.86ˇ

14.82 ± 2.84

12.85 ± 1.35

13.46 ± 0.88

11.88 ± 0.56*

Fpassive (kN/m2)

0.98 ± 0.16

0.8 ± 0.12

1.3 ± 0.14ˇ

1.11 ± 0.16

0.86 ± 0.05§

pCa50

5.8 ± 0.01

5.77 ± 0.02

5.85 ± 0.04

5.76 ± 0.03

5.8 ± 0.01

ktr,max (1/s)

4.51 ± 0.27 + §^ˇ

2.16 ± 0.16*ˇ

1.7 ± 0.09*

1.99 ± 0.1*ˇ

1.53 ± 0.1*+^

nHill

2.74 ± 0.22

2.6 ± 0.06

2.31 ± 0.07

2.42 ± 0.17

2.4 ± 0.06

  1. Fmax = maximum Ca2+-activated active force; Fpassive = Ca2+-independent passive force; pCa50 = Ca2+-sensitivity of isometric force production; ktr,max = rate constant of force redevelopment; nHill = steepness of the force–pCa curve characterising the cooperativity between myofilament units. n = number of animals per group (2–4 cardiomyocytes per animal)
  2. *p < 0.05 vs. CON; +p < 0.05 vs. D-CON; §p < 0.05 vs. BB; ^p < 0.05 vs. ACEI; ˇp < 0.05 vs. AA
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Journal of Translational Medicine

ISSN: 1479-5876

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