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Table 2 Echocardiographic parameters of the animals

From: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy

 

CON (n = 9)

D-CON (n = 8)

BB (n = 6–8)

ACEI (n = 8–9)

AA (n = 11)

BL

FU

BL

FU

BL

FU

BL

FU

BL

FU

EF (%)

84.15 ± 0.87

79.19 ± 1.73#+ˇ

83.71 ± 1.85

71.09 ± 1.69#*§

84.38 ± 1.78

78 ± 2.28+ˇ

85 ± 1.62

72.89 ± 2.56#

85 ± 1.83

68.88 ± 2.23#*§

IVSd (mm)

1.09 ± 0.1

1.21 ± 0.10

1.03 ± 0.04

1.26 ± 0.09

1.13 ± 0.03

1.07 ± 0.04

1.09 ± 0.03

1.07 ± 0.03

1.05 ± 0.05

1.05 ± 0.04

IVSs (mm)

1.66 ± 0.22^

1.56 ± 0.1§^ˇ

1.38 ± 0.14^

1.46 ± 0.04§^ˇ

1.16 ± 0.06

1.15 ± 0.04*+

1.03 ± 0.03*+ˇ

1.09 ± 0.03*+

1.16 ± 0.03^

1.08 ± 0.04*+

PWd (mm)

0.84 ± 0.03

1 ± 0.04#§^ ˇ

0.82 ± 0.04

1.02 ± 0.03#§^ˇ

0.88 ± 0.03

0.9 ± 0.02*+

0.81 ± 0.03

0.81 ± 0.04*+

0.85 ± 0.03

0.89 ± 0.02*+

PWs (mm)

1.34 ± 0.12^ˇ

1.39 ± 0.1§^ˇ

1.22 ± 0.16

1.37 ± 0.11§^ˇ

1.06 ± 0.02ˇ

0.99 ± 0.04*+

0.99 ± 0.05*

1 ± 0.02*+

0.95 ± 0.03*§

0.95 ± 0.02*+

LVEDD (mm)

6.36 ± 0.25§^ˇ

6.76 ± 0.21§^ˇ

5.59 ± 0.35^

6.13 ± 0.33#^

4.87 ± 0.24*

5.72 ± 0.21*

4.5 ± 0.2*+

5.09 ± 0.23#*+

4.81 ± 0.25*

5.32 ± 0.26*

LVESD (mm)

3.31 ± 0.15§^ˇ

3.85 ± 0.19#§

2.92 ± 0.21^

3.95 ± 0.26#^

2.53 ± 0.21*

3.32 ± 0.17*

2.3 ± 0.16*+

3.21 ± 0.23#+

2.44 ± 0.21*

3.5 ± 0.2#

IVCT (ms)

19.41 ± 1.12§

18.18 ± 1.52

19.42 ± 2.58§

22.67 ± 1.93

14.87 ± 0.77*+^

20.54 ± 0.88#

18.07 ± 0.99§

18.67 ± 1ˇ

17.52 ± 0.9

22.82 ± 1.76#^

IVRT (ms)

25.3 ± 1.08

24.63 ± 1.59+§^ˇ

28.48 ± 1.5

33.88 ± 4.41*§

25.79 ± 1.28

38.17 ± 1.8#*+^

28.81 ± 1.67

30.93 ± 1.73*§

27.24 ± 1.59

34.61 ± 1.58#*

DecT (ms)

40.37 ± 1.3

45.56 ± 2.68§^ˇ

37.96 ± 3.58

42.5 ± 2.77^

34.79 ± 3.42

36.63 ± 2.46*

42.04 ± 2.65

33.7 ± 2.1#*+

38.15 ± 2.26

37.79 ± 2.3*

ET (ms)

64.7 ± 2.05+§^ˇ

62.3 ± 1.47+§

59.29 ± 2.39*

81.46 ± 7.77#*^

57.29 ± 3.22*

73.71 ± 1.86#*^

58.59 ± 1.36*

63.93 ± 2.14#+§

56.58 ± 1.66*

68.61 ± 2.84#

E (cm/s)

66.63 ± 2.8

64.26 ± 4.21

60.25 ± 4.81

59.63 ± 1.88

63.67 ± 4.81

60.96 ± 4.09

65.33 ± 2.56

58.89 ± 2.81

60.06 ± 2.98

57.55 ± 3.6

A (cm/s)

47.07 ± 4.1

42.26 ± 3.65ˇ

40.21 ± 4.46

37.29 ± 3.22ˇ

43.78 ± 5.32

34.17 ± 2.16ˇ

48.08 ± 4.53

35.75 ± 3.09#ˇ

43.09 ± 3.04

25.06 ± 2.47#*+§^

e’ (cm/s)

3.63 ± 0.38

4.44 ± 0.3

3.75 ± 0.25§

4.33 ± 0.35

4.58 ± 0.27+^

4.21 ± 0.5

3.59 ± 0.19§

4.44 ± 0.42

4.03 ± 0.28

3.79 ± 0.31

a’ (cm/s)

5.52 ± 0.62

4.41 ± 0.48

4.71 ± 0.39

4.29 ± 0.31

5.57 ± 0.86

4.19 ± 0.71

4.79 ± 0.32

3.88 ± 0.3

5.52 ± 0.55

3.48 ± 0.33#

s’ (cm/s)

27.56 ± 2.38§^ˇ

30.89 ± 1.71

32.67 ± 2.02

29.5 ± 1.6

37.13 ± 1.44*

30.79 ± 1.67#

37.83 ± 1.51*

30.42 ± 1.24#

35.48 ± 2.34*

28.03 ± 1.15#

E/e’

20.11 ± 2.23§

15.09 ± 1.52

16.83 ± 2.06

14.31 ± 1.06

14.25 ± 1.32*^

15.07 ± 0.94

18.53 ± 1.09§

14.32 ± 1.58

15.7 ± 1.48

15.88 ± 1.23

Tei-index

0.7 ± 0.03

0.7 ± 0.05ˇ

0.82 ± 0.09

0.7 ± 0.04ˇ

0.72 ± 0.07

0.8 ± 0.02

0.8 ± 0.04

0.78 ± 0.03

0.79 ± 0.04

0.83 ± 0.04*+

  1. A= mitral A wave; a’ = late diastolic velocity of the mitral anulus; BL = baseline; DecT = deceleration time; E = mitral E wave; e’ = early diastolic velocity of the mitral anulus; EF = ejection fraction; ET = ejection time; FU = follow-up; IVCT = isovolumetric contraction time; IVRT = isovolumetric relaxation time; IVSd = diastolic thickness of the interventricular septum; IVSs = systolic thickness of the interventricular septum; LVEDd = end-diastolic diameter of the left ventricle; LVESd = end-systolic diameter of the left ventricle; PWd = diastolic thickness of the posterior wall; PWs = systolic thickness of the posterior wall; s’ = systolic velocity of the mitral anulus; Tei-index = myocardial performance index [(IVCT + IVRT)/ET]. n = number of animals per group (3 measurements per animal)
  2. *p < 0.05 vs. CON; +p < 0.05 vs. D-CON; §p < 0.05 vs. BB; ^p < 0.05 vs. ACEI; ˇp < 0.05 vs. AA; #p < 0.05 vs. BL