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Table 2 Comparison of plasma immune analytes in plasma and EVs from individuals with ME/CFS and healthy controls

From: Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study

Plasma Extracellular vesicles
Cytokine P-value Q-value CFS/controls Cytokine P-value Q-value CFS/controls
CD40 ligand 0.422 0.863 1.0 CD40 ligand 0.421 0.858 1.0
EGF 0.122 0.863 0.7 EGF 0.331 0.858 0.8
Eotaxin 0.931 0.983 0.9 Eotaxin 0.301 0.858 1.1
FGF-β 1.000 1.000 1.0 FGF-β 0.553 0.858 1.0
Flt3 ligand 0.350 0.863 1.1 Flt3 ligand 0.784 0.909 1.0
Fractalkine 0.118 0.863 1.1 Fractalkine 0.584 0.858 1.0
G-CSF 0.396 0.863 1.0 G-CSF 0.503 0.858 1.0
GM-CSF 1.000 1.000 1.0 GM-CSF 0.089 0.858 1.4
Granzyme B 0.683 0.940 1.0 Granzyme B 0.855 0.933 1.0
Groα 0.773 0.940 1.0 Groα 0.796 0.909 1.1
Groβ 0.313 0.863 0.8 Groβ 0.641 0.858 0.5
IFN-α 0.521 0.937 0.9 IFN-α 0.456 0.858 0.9
IFN-β 0.661 0.940 0.9 IFN-β 0.952 0.952 1.5
IFN-γ 0.737 0.940 1.0 IFN-γ 0.727 0.909 1.1
IL-12p70 0.255 0.863 0.9 IL-12p70 0.104 0.858 1.9
IL-13 0.413 0.863 0.8 IL-13 0.563 0.858 1.0
IL-15 0.726 0.940 1.0 IL-15 0.627 0.858 1.7
IL-17 0.815 0.940 1.0 IL-17 0.386 0.858 1.3
IL-17E 0.630 0.940 0.9 IL-17E 0.049 0.858 0.6
IL-1RA 0.053 0.863 1.2 IL-1RA 0.346 0.858 0.9
IL-1α 0.115 0.863 0.9 IL-1α 0.952 0.952 0.9
IL-1β 0.661 0.940 1.0 IL-1β 0.465 0.858 0.9
IL-2 0.266 0.863 0.9 IL-2 0.202 0.858 1.6
IL-3 0.306 0.863 1.0 IL-3 0.796 0.909 1.1
IL-33 0.380 0.863 1.0 IL-33 0.236 0.858 1.2
IL-4 0.793 0.940 0.9 IL-4 0.616 0.858 0.9
IL-5 0.473 0.925 1.0 IL-5 0.594 0.858 1.1
IL-6 0.903 0.983 1.0 IL-6 0.648 0.858 1.1
IL-7 0.299 0.863 1.0 IL-7 0.378 0.858 1.8
IL-8 0.405 0.863 0.7 IL-8 0.808 0.909 1.2
IL-10 0.803 0.940 1.0 IL-10 0.784 0.909 1.3
IP-10 0.249 0.863 1.4 IP-10 0.162 0.858 1.5
MCP-1 0.008 0.338 1.5 MCP-1 0.022 0.858 1.7
MIP-1α 0.414 0.863 1.3 MIP-1α 0.475 0.858 1.3
MIP-1β 0.939 0.983 1.0 MIP-1β 0.879 0.933 0.9
MIP-3β 0.599 0.940 1.1 MIP-3β 0.891 0.933 1.2
MIP-3α 0.213 0.863 0.9 MIP-3α 0.485 0.858 0.9
PD-L1 0.726 0.940 1.0 PD-L1 0.634 0.858 1.1
PDGF-AA 0.354 0.863 0.9 PDGF-AA 0.425 0.858 0.8
PDGF-BB 0.181 0.863 0.8 PDGF-BB 0.086 0.858 0.6
RANTES 0.116 0.863 0.7 RANTES 0.221 0.858 0.7
TGF-α 0.521 0.937 1.0 TGF-α 0.504 0.858 1.1
TNF-α 0.748 0.940 1.0 TNF-α 0.466 0.858 1.2
TRAIL 0.838 0.942 1.0 TRAIL 0.218 0.858 1.3
VEGF-A 0.683 0.940 1.0 VEGF-A 0.230 0.858 1.1
  1. p-values are shown prior correction for multiple comparison using the Benjamini and Yekutieli control for false discovery rate (q-values) at a 5% rate. Results were adjusted for age and BMI. Also indicated, are ratios of analyte levels ME/CFS vs. controls. Italics values denote statistical significance at p < 0.05