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Table 1 Study population characteristics

From: Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study

  ME/CFS Controls Mann–Whitney U test
Age (years) 50.6 ± 13.7 50.2 ± 17.5 p = 0.42
Gender
 Female 28 28 NA
 Male 7 7 NA
BMI (kg/m2) 24.3 ± 5.3 24.3 ± 4.6 p = 0.18
Onset of disease
 Gradual 40% NA NA
 Sudden 60% NA NA
 Bell score 35.4 ± 14.1 96.3 ± 9.5 p < 0.001
SF-36
 Physical function 44.1 ± 17.2 95.9 ± 7.3 p < 0.001
 Role physical 5.0 ± 11.8 91.4 ± 26.1 p < 0.001
 Pain 40.8 ± 21.6 87.3 ± 14.1 p < 0.001
 General health 25.9 ± 14.5 87.3 ± 15.9 p < 0.001
 Vitality 17.9 ± 15.8 75.4 ± 17.8 p < 0.001
PCSa 26.8 ± 7.5 55.1 ± 5.2 p < 0.001
 Social function 33.6 ± 22.6 94.8 ± 12.3 p < 0.001
 Role emotional 45.7 ± 45.1 91.9 ± 24.6 p < 0.001
 Mental health 59.3 ± 19.8 79.7 ± 18.6 p < 0.001
MCSa 38.9 ± 10.9 53.4 ± 9.6 p < 0.001
SSSa
 Fatigue 6.9 ± 2.5 1.4 ± 1.7 p < 0.001
 Impaired memory 6.4 ± 2.8 0.8 ± 1.4 p < 0.001
 Recurrent sore throat 3.9 ± 3.3 0.4 ± 1.1 p < 0.001
 Tender lymph nodes 3.9 ± 3.1 0.1 ± 0.4 p < 0.001
 Muscle tenderness or pain 5.5 ± 2.9 1.5 ± 1.9 p < 0.001
 Joint pain 5.1 ± 2.9 1.5 ± 2.0 p < 0.001
 Headache 5.0 ± 3.4 0.7 ± 1.4 p < 0.001
 Disturbed sleep or waking unrefreshed 7.6 ± 3.0 1.6 ± 2.1 p < 0.001
 Post-exertional malaise 7.8 ± 2.7 0.8 ± 1.7 p < 0.001
  1. aPCS Physical component score, MCS Mental component score, SSS Specific symptom severity (0 = none, 10 = very severe)