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Table 3 Correlation analysis between leptin levels and parameters of biomarkers and cardiovascular autonomic functions

From: Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes

Variables

Leptin, ng/mL

r

P value

Age (year)

−0.10

0.33

Diabetes duration (year)

−0.023

0.821

Body mass index

0.588

 < 0.0001**

Waist circumference (cm)

0.504

 < 0.0001**

SBP (mmHg)

0.007

0.946

DBP (mmHg)

−0.053

0.597

HbA1c (%)

0.175

0.076

eGFR

−0.175

0.09

UACR

0.351

0.001**

hs-CRP

0.291

0.006**

TBARS, μmol/L

0.259

0.008**

Thiols, μmol/L

−0.25

0.011*

sICAM-1 (ng/ml)

0.122

0.216

sVCAM-1 (ng/ml)

0.109

0.271

Triglyceride/HDL-C ratio

0.346

 < 0.0001

HOMA-IR

0.304

0.008

HR_DB

−0.30

0.002**

Valsalva ratio

−0.31

0.002**

Delta SBP

0.031

0.80

E:I ratio

−0.26

0.008**

30/15 ratio

−0.18

0.07

  1. n number of cases, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1c glycohemoglobin, eGFR estimated glomerular filtration rate, hs-CRP high-sensitive C-reactive protein, UACR urine albumin-creatine ratio, HOMA-IR homeostasis model assessment of IR, HR_DB heart rate response to deep breathing, Delta SBP The change between minimum systolic blood pressure during head-up tilt and baseline systolic blood pressure
  2. *P < 0.05
  3. **P < 0.01
  4. ***P < 0.001
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Journal of Translational Medicine

ISSN: 1479-5876

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